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Subclinical Alterations of Cardiac Mechanics Present Early in the Course of Pediatric Type 1 Diabetes Mellitus: A Prospective Blinded Speckle Tracking Stress Echocardiography Study
Joint Authors
Hensel, Kai O.
Grimmer, Franziska
Roskopf, Markus
Wirth, Stefan
Heusch, Andreas
Jenke, Andreas
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-29
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Diabetic cardiomyopathy substantially accounts for mortality in diabetes mellitus.
The pathophysiological mechanism underlying diabetes-associated nonischemic heart failure is poorly understood and clinical data on myocardial mechanics in early stages of diabetes are lacking.
In this study we utilize speckle tracking echocardiography combined with physical stress testing in order to evaluate whether left ventricular (LV) myocardial performance is altered early in the course of uncomplicated type 1 diabetes mellitus (T1DM).
40 consecutive asymptomatic normotensive children and adolescents with T1DM (mean age 11.5 ± 3.1 years and mean disease duration 4.3 ± 3.5 years) and 44 age- and gender-matched healthy controls were assessed using conventional and quantitative echocardiography (strain and strain rate) during bicycle ergometer stress testing.
Strikingly, T1DM patients had increased LV longitudinal ( p = 0.019 ) and circumferential ( p = 0.016 ) strain rate both at rest and during exercise ( p = 0.021 ).
This was more pronounced in T1DM patients with a longer disease duration ( p = 0.038 ).
T1DM patients with serum H b A 1 c > 9 % showed impaired longitudinal ( p = 0.008 ) and circumferential strain ( p = 0.005 ) and a reduced E/A-ratio ( p = 0.018 ).
In conclusion, asymptomatic T1DM patients have signs of hyperdynamic LV contractility early in the course of the disease.
Moreover, poor glycemic control is associated with early subclinical LV systolic and diastolic impairment.
American Psychological Association (APA)
Hensel, Kai O.& Grimmer, Franziska& Roskopf, Markus& Jenke, Andreas& Wirth, Stefan& Heusch, Andreas. 2015. Subclinical Alterations of Cardiac Mechanics Present Early in the Course of Pediatric Type 1 Diabetes Mellitus: A Prospective Blinded Speckle Tracking Stress Echocardiography Study. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1108022
Modern Language Association (MLA)
Hensel, Kai O.…[et al.]. Subclinical Alterations of Cardiac Mechanics Present Early in the Course of Pediatric Type 1 Diabetes Mellitus: A Prospective Blinded Speckle Tracking Stress Echocardiography Study. Journal of Diabetes Research No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1108022
American Medical Association (AMA)
Hensel, Kai O.& Grimmer, Franziska& Roskopf, Markus& Jenke, Andreas& Wirth, Stefan& Heusch, Andreas. Subclinical Alterations of Cardiac Mechanics Present Early in the Course of Pediatric Type 1 Diabetes Mellitus: A Prospective Blinded Speckle Tracking Stress Echocardiography Study. Journal of Diabetes Research. 2015. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1108022
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108022