Circulating Levels of Betatrophin and Irisin Are Not Associated with Pancreatic β-Cell Function in Previously Diagnosed Type 2 Diabetes Mellitus Patients
Joint Authors
Zhao, Ruxing
Liang, Kai
Sun, Yu
Li, Wen-juan
He, Tianyi
Lu, Yiran
Hou, Xinguo
Wang, Lingshu
Song, Jun
Wang, Chuan
Lin, Peng
Qin, Jun
Liu, Jinbo
Liu, Fuqiang
Chen, Li
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-16
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Betatrophin and irisin are two recently identified hormones which may participate in regulating pancreatic β-cell function.
However, the associations of these two hormones with β-cell function remain unclear.
The present study aims to demonstrate the associations of circulating betatrophin and irisin levels with β-cell function, assessed by the area under the curve (AUC) of C-peptide, and the possible correlation between these two hormones in previously diagnosed type 2 diabetes mellitus (T2DM) patients.
In total, 20 age-, sex-, and body mass index- (BMI-) matched normal glucose tolerance (NGT) subjects and 120 previously diagnosed T2DM patients were included in this study.
Partial correlation analysis was used to evaluate the relationships between these two hormones and indexes of β-cell function and insulin resistance.
Our results showed that betatrophin levels were significantly elevated, while irisin levels were significantly decreased, in patients with T2DM compared with NGT subjects.
However, partial correlation analysis showed that betatrophin levels did not correlate with β-cell function-related variables or insulin resistance-related variables before or after controlling multiple covariates, while irisin correlated positively with insulin sensitivity but is not associated with β-cell function-related variables.
Besides, no correlation was observed between betatrophin and irisin levels.
Hence we concluded that betatrophin and irisin were not associated with β-cell function in previously diagnosed T2DM patients.
American Psychological Association (APA)
Wang, Lingshu& Song, Jun& Wang, Chuan& Lin, Peng& Liang, Kai& Sun, Yu…[et al.]. 2015. Circulating Levels of Betatrophin and Irisin Are Not Associated with Pancreatic β-Cell Function in Previously Diagnosed Type 2 Diabetes Mellitus Patients. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1108024
Modern Language Association (MLA)
Wang, Lingshu…[et al.]. Circulating Levels of Betatrophin and Irisin Are Not Associated with Pancreatic β-Cell Function in Previously Diagnosed Type 2 Diabetes Mellitus Patients. Journal of Diabetes Research No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1108024
American Medical Association (AMA)
Wang, Lingshu& Song, Jun& Wang, Chuan& Lin, Peng& Liang, Kai& Sun, Yu…[et al.]. Circulating Levels of Betatrophin and Irisin Are Not Associated with Pancreatic β-Cell Function in Previously Diagnosed Type 2 Diabetes Mellitus Patients. Journal of Diabetes Research. 2015. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1108024
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108024