The Role of Matrix Metalloproteinases in Diabetic Wound Healing in relation to Photobiomodulation
Joint Authors
Houreld, Nicolette Nadene
Ayuk, Sandra M.
Abrahamse, H.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-23
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The integration of several cellular responses initiates the process of wound healing.
Matrix Metalloproteinases (MMPs) play an integral role in wound healing.
Their main function is degradation, by removal of damaged extracellular matrix (ECM) during the inflammatory phase, breakdown of the capillary basement membrane for angiogenesis and cell migration during the proliferation phase, and contraction and remodelling of tissue in the remodelling phase.
For effective healing to occur, all wounds require a certain amount of these enzymes, which on the contrary could be very damaging at high concentrations causing excessive degradation and impaired wound healing.
The imbalance in MMPs may increase the chronicity of a wound, a familiar problem seen in diabetic patients.
The association of diabetes with impaired wound healing and other vascular complications is a serious public health issue.
These may eventually lead to chronic foot ulcers and amputation.
Low intensity laser irradiation (LILI) or photobiomodulation (PBM) is known to stimulate several wound healing processes; however, its role in matrix proteins and diabetic wound healing has not been fully investigated.
This review focuses on the role of MMPs in diabetic wound healing and their interaction in PBM.
American Psychological Association (APA)
Ayuk, Sandra M.& Abrahamse, H.& Houreld, Nicolette Nadene. 2016. The Role of Matrix Metalloproteinases in Diabetic Wound Healing in relation to Photobiomodulation. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1108037
Modern Language Association (MLA)
Ayuk, Sandra M.…[et al.]. The Role of Matrix Metalloproteinases in Diabetic Wound Healing in relation to Photobiomodulation. Journal of Diabetes Research No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1108037
American Medical Association (AMA)
Ayuk, Sandra M.& Abrahamse, H.& Houreld, Nicolette Nadene. The Role of Matrix Metalloproteinases in Diabetic Wound Healing in relation to Photobiomodulation. Journal of Diabetes Research. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1108037
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108037