n-3 Polyunsaturated Fatty Acid Supplementation Has No Effect on Postprandial Triglyceride-Rich Lipoprotein Kinetics in Men with Type 2 Diabetes
Joint Authors
Lamarche, Benoît
Tremblay, André J.
Hogue, Jean-Charles
Couture, Patrick
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-29
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Dietary n-3 polyunsaturated fatty acids (PUFAs) have been proposed to modulate plasma lipids, lipoprotein metabolism, and inflammatory state and to reduce triglyceride (TG) concentrations.
The present double-blind, randomized, placebo-controlled, crossover study investigated the effects of n-3 PUFA supplementation at 3 g/d for 8 weeks on the intravascular kinetics of intestinally derived apolipoprotein (apo) B-48-containing lipoproteins in 10 men with type 2 diabetes.
In vivo kinetics of the TG-rich lipoprotein (TRL) apoB-48 and VLDL apoB-100 were assessed using a primed-constant infusion of L-[5,5,5-D3] leucine for 12 hours in a fed state.
Compared with the placebo, n-3 PUFA supplementation significantly reduced fasting TG concentrations by −9.7% ( P = 0.05 ) but also significantly increased plasma levels of cholesterol (C) (+6.0%, P = 0.05 ), LDL-C (+12.2%, P = 0.04 ), and HDL-C (+8.4, P = 0.007 ).
n-3 PUFA supplementation had no significant impact on postprandial TRL apoB-48 and VLDL apoB-100 levels or on the production or catabolic rates of these lipoproteins.
These data indicate that 8-week supplementation with n-3 PUFAs in men with type 2 diabetes has no beneficial effect on TRL apoB-48 and VLDL apoB-100 levels or kinetics.
American Psychological Association (APA)
Tremblay, André J.& Lamarche, Benoît& Hogue, Jean-Charles& Couture, Patrick. 2016. n-3 Polyunsaturated Fatty Acid Supplementation Has No Effect on Postprandial Triglyceride-Rich Lipoprotein Kinetics in Men with Type 2 Diabetes. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1108039
Modern Language Association (MLA)
Tremblay, André J.…[et al.]. n-3 Polyunsaturated Fatty Acid Supplementation Has No Effect on Postprandial Triglyceride-Rich Lipoprotein Kinetics in Men with Type 2 Diabetes. Journal of Diabetes Research No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1108039
American Medical Association (AMA)
Tremblay, André J.& Lamarche, Benoît& Hogue, Jean-Charles& Couture, Patrick. n-3 Polyunsaturated Fatty Acid Supplementation Has No Effect on Postprandial Triglyceride-Rich Lipoprotein Kinetics in Men with Type 2 Diabetes. Journal of Diabetes Research. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1108039
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108039