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Gluten-Free Diet Only during Pregnancy Efficiently Prevents Diabetes in NOD Mouse Offspring
Joint Authors
Buschard, K.
Haupt-Jorgensen, Martin
Antvorskov, Julie C.
Fundova, Petra
Funda, David P.
Josefsen, K.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-25
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Studies have documented that the pathogenesis of autoimmune diabetes is influenced by the intake of gluten.
Aims.
To investigate the importance of gluten exposure during pregnancy and the subsequent development of autoimmune diabetes in offspring.
Methods.
Nonobese diabetic mice were divided into 7 groups to receive combinations of gluten-free and standard diet before, during, or after pregnancy.
Diabetes incidence in offspring was followed in each group ( n = 16 – 27 ) for 310 days.
Insulitis score and intestinal expression of T-cell transcription factors (RT-QPCR) were evaluated in animals from the different diet groups.
Results.
If mothers were fed a gluten-free diet only during pregnancy, the development of autoimmune diabetes in offspring was almost completely prevented with an incidence reduction from 62.5% in gluten-consuming mice to 8.3% ( p < 0.0001 ) in the gluten-free group.
The islets of Langerhans were less infiltrated ( p < 0.001 ) and the intestinal expression of RORγt (Th17) ( p < 0.0001 ) reduced in mice whose mothers were Gluten-free during pregnancy.
Conclusion.
A gluten-free diet exclusively during pregnancy efficiently prevents autoimmune diabetes development in offspring and reduces insulitis and intestinal expression of RORγt (Th17).
American Psychological Association (APA)
Antvorskov, Julie C.& Josefsen, K.& Haupt-Jorgensen, Martin& Fundova, Petra& Funda, David P.& Buschard, K.. 2016. Gluten-Free Diet Only during Pregnancy Efficiently Prevents Diabetes in NOD Mouse Offspring. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1108048
Modern Language Association (MLA)
Antvorskov, Julie C.…[et al.]. Gluten-Free Diet Only during Pregnancy Efficiently Prevents Diabetes in NOD Mouse Offspring. Journal of Diabetes Research No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1108048
American Medical Association (AMA)
Antvorskov, Julie C.& Josefsen, K.& Haupt-Jorgensen, Martin& Fundova, Petra& Funda, David P.& Buschard, K.. Gluten-Free Diet Only during Pregnancy Efficiently Prevents Diabetes in NOD Mouse Offspring. Journal of Diabetes Research. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1108048
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108048