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Potentiation of Calcium Influx and Insulin Secretion in Pancreatic Beta Cell by the Specific TREK-1 Blocker Spadin
Joint Authors
Mazella, J.
Abderrahmani, Amar
Hivelin, Céline
Béraud-Dufour, Sophie
Devader, Christelle
Moreno, Sébastien
Moha ou Maati, Hamid
Djillani, Alaeddine
Heurteaux, Catherine
Borsotto, Marc
Coppola, Thierry
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-25
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Inhibition of the potassium channels TREK-1 by spadin (SPA) is currently thought to be a promising therapeutic target for the treatment of depression.
Since these channels are expressed in pancreatic β-cells, we investigated their role in the control of insulin secretion and glucose homeostasis.
In this study, we confirmed the expression of TREK-1 channels in the insulin secreting MIN6-B1 β-cell line and in mouse islets.
We found that their blockade by SPA potentiated insulin secretion induced by potassium chloride dependent membrane depolarization.
Inhibition of TREK-1 by SPA induced a decrease of the resting membrane potential (ΔVm~12 mV) and increased the cytosolic calcium concentration.
In mice, administration of SPA enhanced the plasma insulin level stimulated by glucose, confirming its secretagogue effect observed in vitro.
Taken together, this work identifies SPA as a novel potential pharmacological agent able to control insulin secretion and glucose homeostasis.
American Psychological Association (APA)
Hivelin, Céline& Béraud-Dufour, Sophie& Devader, Christelle& Abderrahmani, Amar& Moreno, Sébastien& Moha ou Maati, Hamid…[et al.]. 2016. Potentiation of Calcium Influx and Insulin Secretion in Pancreatic Beta Cell by the Specific TREK-1 Blocker Spadin. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1108050
Modern Language Association (MLA)
Hivelin, Céline…[et al.]. Potentiation of Calcium Influx and Insulin Secretion in Pancreatic Beta Cell by the Specific TREK-1 Blocker Spadin. Journal of Diabetes Research No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1108050
American Medical Association (AMA)
Hivelin, Céline& Béraud-Dufour, Sophie& Devader, Christelle& Abderrahmani, Amar& Moreno, Sébastien& Moha ou Maati, Hamid…[et al.]. Potentiation of Calcium Influx and Insulin Secretion in Pancreatic Beta Cell by the Specific TREK-1 Blocker Spadin. Journal of Diabetes Research. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1108050
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108050