![](/images/graphics-bg.png)
Metabolomics and Type 2 Diabetes: Translating Basic Research into Clinical Application
Joint Authors
Klein, Matthias S.
Shearer, Jane
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-09
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Type 2 diabetes (T2D) and its comorbidities have reached epidemic proportions, with more than half a billion cases expected by 2030.
Metabolomics is a fairly new approach for studying metabolic changes connected to disease development and progression and for finding predictive biomarkers to enable early interventions, which are most effective against T2D and its comorbidities.
In metabolomics, the abundance of a comprehensive set of small biomolecules (metabolites) is measured, thus giving insight into disease-related metabolic alterations.
This review shall give an overview of basic metabolomics methods and will highlight current metabolomics research successes in the prediction and diagnosis of T2D.
We summarized key metabolites changing in response to T2D.
Despite large variations in predictive biomarkers, many studies have replicated elevated plasma levels of branched-chain amino acids and their derivatives, aromatic amino acids and α-hydroxybutyrate ahead of T2D manifestation.
In contrast, glycine levels and lysophosphatidylcholine C18:2 are depressed in both predictive studies and with overt disease.
The use of metabolomics for predicting T2D comorbidities is gaining momentum, as are our approaches for translating basic metabolomics research into clinical applications.
As a result, metabolomics has the potential to enable informed decision-making in the realm of personalized medicine.
American Psychological Association (APA)
Klein, Matthias S.& Shearer, Jane. 2015. Metabolomics and Type 2 Diabetes: Translating Basic Research into Clinical Application. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1108085
Modern Language Association (MLA)
Klein, Matthias S.& Shearer, Jane. Metabolomics and Type 2 Diabetes: Translating Basic Research into Clinical Application. Journal of Diabetes Research No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1108085
American Medical Association (AMA)
Klein, Matthias S.& Shearer, Jane. Metabolomics and Type 2 Diabetes: Translating Basic Research into Clinical Application. Journal of Diabetes Research. 2015. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1108085
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108085