Abnormal Glucose Tolerance Is Associated with a Reduced Myocardial Metabolic Flexibility in Patients with Dilated Cardiomyopathy
Joint Authors
Tricò, Domenico
Baldi, Simona
Frascerra, Silvia
Venturi, Elena
Marraccini, Paolo
Neglia, Danilo
Natali, Andrea
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-21
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Dilated cardiomyopathy (DCM) is characterized by a metabolic shift from fat to carbohydrates and failure to increase myocardial glucose uptake in response to workload increments.
We verified whether this pattern is influenced by an abnormal glucose tolerance (AGT).
In 10 patients with DCM, 5 with normal glucose tolerance (DCM-NGT) and 5 with AGT (DCM-AGT), and 5 non-DCM subjects with AGT (N-AGT), we measured coronary blood flow and arteriovenous differences of oxygen and metabolites during Rest, Pacing (at 130 b/min), and Recovery.
Myocardial lactate exchange and oleate oxidation were also measured.
At Rest, DCM patients showed a reduced nonesterified fatty acids (NEFA) myocardial uptake, while glucose utilization increased only in DCM-AGT.
In response to Pacing, glucose uptake promptly rose in N-AGT (from 72 ± 21 to 234 ± 73 nmol/min/g, p<0.05), did not change in DCM-AGT, and slowly increased in DCM-NGT.
DCM-AGT sustained the extra workload by increasing NEFA oxidation (from 1.3 ± 0.2 to 2.9 ± 0.1 μmol/min/gO2 equivalents, p<0.05), while DCM-NGT showed a delayed increase in glucose uptake.
Substrate oxidation rates paralleled the metabolites data.
The presence of AGT in patients with DCM exacerbates both the shift from fat to carbohydrates in resting myocardial metabolism and the reduced myocardial metabolic flexibility in response to an increased workload.
This trial is registered with ClinicalTrial.gov NCT02440217.
American Psychological Association (APA)
Tricò, Domenico& Baldi, Simona& Frascerra, Silvia& Venturi, Elena& Marraccini, Paolo& Neglia, Danilo…[et al.]. 2015. Abnormal Glucose Tolerance Is Associated with a Reduced Myocardial Metabolic Flexibility in Patients with Dilated Cardiomyopathy. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1108086
Modern Language Association (MLA)
Tricò, Domenico…[et al.]. Abnormal Glucose Tolerance Is Associated with a Reduced Myocardial Metabolic Flexibility in Patients with Dilated Cardiomyopathy. Journal of Diabetes Research No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1108086
American Medical Association (AMA)
Tricò, Domenico& Baldi, Simona& Frascerra, Silvia& Venturi, Elena& Marraccini, Paolo& Neglia, Danilo…[et al.]. Abnormal Glucose Tolerance Is Associated with a Reduced Myocardial Metabolic Flexibility in Patients with Dilated Cardiomyopathy. Journal of Diabetes Research. 2015. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1108086
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108086