Brain Activation during Memory Encoding in Type 2 Diabetes Mellitus: A Discordant Twin Pair Study
Joint Authors
Phan, T. G.
Wood, Amanda G.
Chen, Jian
Moran, Christopher
Beare, Richard
Cooper, Kimberley
Litras, Stacey
Srikanth, Velandai
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-29
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Type 2 diabetes mellitus increases the risk of dementia and neuronal dysfunction may occur years before perceptible cognitive decline.
We aimed to study the impact of type 2 diabetes on brain activation during memory encoding in middle-aged people, controlling for age, sex, genes, and early-shared environment.
Twenty-two twin pairs discordant for type 2 diabetes mellitus (mean age 60.9 years) without neurological disease were recruited from the Australian Twin Registry (ATR) and underwent functional magnetic resonance imaging (fMRI) during a memory encoding task, cognitive tests, and structural MRI.
Type 2 diabetes was associated with significantly reduced activation in left hemisphere temporoparietal regions including angular gyrus, supramarginal gyrus, and middle temporal gyrus and significantly increased activation in bilateral posteriorly distributed regions.
These findings were present in the absence of within-pair differences in standard cognitive test scores, brain volumes, or vascular lesion load.
Differences in activation were more pronounced among monozygotic (MZ) pairs, with MZ individuals with diabetes also displaying greater frontal activation.
These results provide evidence for preclinical memory-related neuronal dysfunction in type 2 diabetes.
They support the search for modifiable later-life environmental factors or epigenetic mechanisms linking type 2 diabetes and cognitive decline.
American Psychological Association (APA)
Wood, Amanda G.& Chen, Jian& Moran, Christopher& Phan, T. G.& Beare, Richard& Cooper, Kimberley…[et al.]. 2016. Brain Activation during Memory Encoding in Type 2 Diabetes Mellitus: A Discordant Twin Pair Study. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1108090
Modern Language Association (MLA)
Wood, Amanda G.…[et al.]. Brain Activation during Memory Encoding in Type 2 Diabetes Mellitus: A Discordant Twin Pair Study. Journal of Diabetes Research No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1108090
American Medical Association (AMA)
Wood, Amanda G.& Chen, Jian& Moran, Christopher& Phan, T. G.& Beare, Richard& Cooper, Kimberley…[et al.]. Brain Activation during Memory Encoding in Type 2 Diabetes Mellitus: A Discordant Twin Pair Study. Journal of Diabetes Research. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1108090
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108090