Reversal of Early Diabetic Nephropathy by Islet Transplantation under the Kidney Capsule in a Rat Model
Joint Authors
Zhou, Mengtao
Chen, Bi-Cheng
He, Yunqiang
Xu, Ziqiang
Zhou, Mingshi
Wu, Minmin
Chen, Xuehai
Wang, Silu
Qiu, Kaiyan
Cai, Yong
Fu, Hongxing
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-20
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Objective.
Diabetic nephropathy (DN) is a common microvascular complication of diabetes mellitus, and insulin therapy has many side effects in the treatment of DN.
Islet transplantation has emerged as a promising therapy for diabetic patients.
This study was established to investigate its advantageous effects in a rat model of early DN.
Methods.
Streptozotocin was administered to the rats to induce diabetes.
Twelve weeks later, the diabetic rats were divided into 3 groups: the islet-transplanted group (IT group), the insulin-treated group (IN group), and the untreated group (DN group).
Renal injury and kidney structure were assessed by urinalysis and transmission electron microscopy (TEM) detection.
Immunohistochemical staining and western blotting were performed to assess renal fibrosis levels.
Results.
The early DN features were reversed and the glomerular filtration barrier and basement membrane structures were improved at 4 weeks after islet transplantation.
The urine microalbumin-to-creatinine ratio (ACR), protein-to-creatinine ratio, and mean thickness of the glomerular basement membrane (GBM) were significantly decreased in the IT group.
The expression of renal fibrotic factors was also significantly decreased.
Conclusions.
These data suggest that early DN can be reversed after islet transplantation, and they may facilitate the development of a clinical therapeutic strategy for human diabetes mellitus.
American Psychological Association (APA)
He, Yunqiang& Xu, Ziqiang& Zhou, Mingshi& Wu, Minmin& Chen, Xuehai& Wang, Silu…[et al.]. 2016. Reversal of Early Diabetic Nephropathy by Islet Transplantation under the Kidney Capsule in a Rat Model. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1108099
Modern Language Association (MLA)
He, Yunqiang…[et al.]. Reversal of Early Diabetic Nephropathy by Islet Transplantation under the Kidney Capsule in a Rat Model. Journal of Diabetes Research No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1108099
American Medical Association (AMA)
He, Yunqiang& Xu, Ziqiang& Zhou, Mingshi& Wu, Minmin& Chen, Xuehai& Wang, Silu…[et al.]. Reversal of Early Diabetic Nephropathy by Islet Transplantation under the Kidney Capsule in a Rat Model. Journal of Diabetes Research. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1108099
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108099