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Longitudinal Frequencies of Blood Leukocyte Subpopulations Differ between NOD and NOR Mice but Do Not Predict Diabetes in NOD Mice
Joint Authors
Telieps, Tanja
Köhler, Meike
Treise, Irina
Foertsch, Katharina
Adler, Thure
Busch, Dirk H.
Hrabě de Angelis, Martin
Verschoor, Admar
Adler, Kerstin
Bonifacio, Ezio
Ziegler, Anette-Gabriele
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-04
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Immune phenotyping provides insight into disease pathogenesis and prognostic markers.
Trajectories from age of 4 to 36 weeks were modeled for insulin autoantibodies and for leukocyte subpopulations in peripheral blood from female NOD ( n = 58 ) and NOR ( n = 22 ) mice.
NOD mice had higher trajectories of insulin autoantibodies, CD4+ and CD8+ T lymphocytes, B lymphocytes, IgD+IgM− B lymphocytes, and NK cells and lower trajectories of CD4+CD25+ T lymphocytes, IgM+ B lymphocytes, granulocytes, and monocytes than NOR mice (all p < 0.001 ).
Of these, only the increased IAA trajectory was observed in NOD mice that developed diabetes as compared to NOD mice that remained diabetes-free.
Therefore, the profound differences in peripheral blood leukocyte proportions observed between the diabetes-prone NOD mice and the diabetes-resistant mice do not explain the variation in diabetes development within NOD mice and do not provide markers for diabetes prediction in this model.
American Psychological Association (APA)
Telieps, Tanja& Köhler, Meike& Treise, Irina& Foertsch, Katharina& Adler, Thure& Busch, Dirk H.…[et al.]. 2016. Longitudinal Frequencies of Blood Leukocyte Subpopulations Differ between NOD and NOR Mice but Do Not Predict Diabetes in NOD Mice. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1108103
Modern Language Association (MLA)
Telieps, Tanja…[et al.]. Longitudinal Frequencies of Blood Leukocyte Subpopulations Differ between NOD and NOR Mice but Do Not Predict Diabetes in NOD Mice. Journal of Diabetes Research No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1108103
American Medical Association (AMA)
Telieps, Tanja& Köhler, Meike& Treise, Irina& Foertsch, Katharina& Adler, Thure& Busch, Dirk H.…[et al.]. Longitudinal Frequencies of Blood Leukocyte Subpopulations Differ between NOD and NOR Mice but Do Not Predict Diabetes in NOD Mice. Journal of Diabetes Research. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1108103
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108103