Association of Postbreakfast Triglyceride and Visit-to-Visit Annual Variation of Fasting Plasma Glucose with Progression of Diabetic Nephropathy in Patients with Type 2 Diabetes
Joint Authors
Kazumi, Tsutomu
Fukuo, Keisuke
Takenouchi, Akiko
Tsuboi, Ayaka
Kitaoka, Kaori
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-15
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Urinary albumin/creatinine ratio (ACR) was measured at baseline and after a median follow-up of 6.0 years in 161 patients with type 2 diabetes.
Intrapersonal means and SD of HbA1c, systolic BP, fasting, and postmeal plasma glucose (FPG and PMPG, resp.) and serum triglycerides (FTG and PMTG, resp.) were calculated in each patient during the first 12 months after enrollment.
Associations of these variables with nephropathy progression (15 patients with progression of albuminuric stages and 5 with ACR doubling within the microalbuminuric range) were determined by multivariate logistic regression analysis providing odds ratio with 95% confidential interval.
Patients with nephropathy progression, compared with those without nephropathy progression, had higher HbA1c (p<0.01).
They also had higher means and SD of FPG (both p<0.05), FTG (both p<0.05), and PMTG (p=0.001).
Multivariate logistic regression analysis demonstrated that SD-FPG (1.036, 1.001–1.073, p=0.04) and PMTG (1.013, 1.008–1.040, p=0.001) were significant predictors of progression of nephropathy even after adjustment for mean FPG and SD-FTG, age, sex, BMI, waist circumference, diabetes duration and therapy, means and SDs of HbA1c, PPG, FTG and systolic BP, baseline ACR, smoking status, and uses of antihypertensive and lipid-lowering medications.
Consistency of glycemic control and management of postmeal TG may be important to prevent nephropathy progression in type 2 diabetic patients.
American Psychological Association (APA)
Kitaoka, Kaori& Takenouchi, Akiko& Tsuboi, Ayaka& Fukuo, Keisuke& Kazumi, Tsutomu. 2016. Association of Postbreakfast Triglyceride and Visit-to-Visit Annual Variation of Fasting Plasma Glucose with Progression of Diabetic Nephropathy in Patients with Type 2 Diabetes. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1108107
Modern Language Association (MLA)
Kitaoka, Kaori…[et al.]. Association of Postbreakfast Triglyceride and Visit-to-Visit Annual Variation of Fasting Plasma Glucose with Progression of Diabetic Nephropathy in Patients with Type 2 Diabetes. Journal of Diabetes Research No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1108107
American Medical Association (AMA)
Kitaoka, Kaori& Takenouchi, Akiko& Tsuboi, Ayaka& Fukuo, Keisuke& Kazumi, Tsutomu. Association of Postbreakfast Triglyceride and Visit-to-Visit Annual Variation of Fasting Plasma Glucose with Progression of Diabetic Nephropathy in Patients with Type 2 Diabetes. Journal of Diabetes Research. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1108107
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108107