Studies on the Antidiabetic and Antinephritic Activities of Paecilomyces hepiali Water Extract in Diet-Streptozotocin-Induced Diabetic Sprague Dawley Rats
Joint Authors
Wang, Juan
Teng, Lirong
Liu, Yange
Hu, Wenji
Chen, Wenqi
Hu, Xi
Wang, Yingwu
Wang, Di
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-29
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Paecilomyces hepiali is a fungus widely used in Asian countries for various potential pharmacological activities.
The present study aims to evaluate the antidiabetic and antinephritic effects of the Paecilomyces hepiali mycelium water extract (PHC) in diabetic rat, which is established by eight-week high-fat diet administration followed by one-week tail intravenous injection of 25 mg/kg streptozotocin (STZ).
After four-week 0.12 g/kg metformin and PHC at doses of 0.08, 0.4, and 2.0 g/kg treatment, an increment of body weight, a decrement of plasma glucose, low levels of total cholesterol, and low density lipoprotein cholesterol in diabetic rats were observed.
PHC promotes glucose metabolism by enhancing insulin, pyruvate kinase activity, and increasing the synthesis of glycogen.
PHC normalized the disturbed levels of superoxide dismutase, methane dicarboxylic aldehyde, and glutathione peroxidase in kidney.
The inhibitory effects on the levels of interleukin-2, interleukin-6, interleukin-10, and tumor necrosis factor- α in serum and kidney revealed the protection of PHC against diabetic nephropathy.
Compared with nontreated diabetic rats, four-week PHC treatment resulted in a decrement on nuclear factor kappa B expression in kidney.
These results show that Paecilomyces hepiali possesses antidiabetic and antinephritic effects which are related to the modulation of nuclear factor kappa B activity.
American Psychological Association (APA)
Wang, Juan& Teng, Lirong& Liu, Yange& Hu, Wenji& Chen, Wenqi& Hu, Xi…[et al.]. 2016. Studies on the Antidiabetic and Antinephritic Activities of Paecilomyces hepiali Water Extract in Diet-Streptozotocin-Induced Diabetic Sprague Dawley Rats. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1108110
Modern Language Association (MLA)
Wang, Juan…[et al.]. Studies on the Antidiabetic and Antinephritic Activities of Paecilomyces hepiali Water Extract in Diet-Streptozotocin-Induced Diabetic Sprague Dawley Rats. Journal of Diabetes Research No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1108110
American Medical Association (AMA)
Wang, Juan& Teng, Lirong& Liu, Yange& Hu, Wenji& Chen, Wenqi& Hu, Xi…[et al.]. Studies on the Antidiabetic and Antinephritic Activities of Paecilomyces hepiali Water Extract in Diet-Streptozotocin-Induced Diabetic Sprague Dawley Rats. Journal of Diabetes Research. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1108110
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108110