Xanthine Oxidase Activity in Type 2 Diabetes Mellitus Patients with and without Diabetic Peripheral Neuropathy
Joint Authors
Dragojevic, Ilija
Miric, Dijana
Grbic, Rade
Filipovic-Danic, Snezana
Miric, Marko B.
Puhalo-Sladoje, Dragana
Kisic, Bojana
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-14
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
This study investigated the relationship between serum xanthine oxidase (XOD) activity and the occurrence of diabetic peripheral neuropathy (DPN) in type 2 diabetes mellitus (T2DM) patients.
Serum XOD activity, ischemia-modified albumin (IMA), uric acid (UA), albumin, glycated hemoglobin (HbA1c), advanced glycation end products (AGE), total free thiols, atherogenic index of plasma (AIP), and body mass index (BMI) were measured in 80 T2DM patients (29 with and 51 without DPN), and 30 nondiabetic control subjects.
Duration of diabetes, hypertension, medication, and microalbuminuria was recorded.
Serum XOD activities in controls, non-DPN, and DPN were 5.7 ± 2.4 U/L, 20.3 ± 8.6 U/L, and 27.5 ± 10.6 U/L ( p < 0.01 ), respectively.
XOD activity was directly correlated to IMA, UA, BMI, HbA1c, and AGE, while inversely correlated to serum total free thiols.
A multivariable logistic regression model, which included duration of diabetes, hypertension, AIP, HbA1c, UA, and XOD activity, revealed HbA1c [OR = 1.03 (1.00–1.05); p = 0.034 ] and XOD activity [OR = 1.07 (1.00–1.14); p = 0.036 ] as independent predictors of DPN.
Serum XOD activity was well correlated to several other risk factors.
These results indicate the role of XOD in the development of DPN among T2DM patients.
American Psychological Association (APA)
Miric, Dijana& Kisic, Bojana& Filipovic-Danic, Snezana& Grbic, Rade& Dragojevic, Ilija& Miric, Marko B.…[et al.]. 2016. Xanthine Oxidase Activity in Type 2 Diabetes Mellitus Patients with and without Diabetic Peripheral Neuropathy. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1108111
Modern Language Association (MLA)
Miric, Dijana…[et al.]. Xanthine Oxidase Activity in Type 2 Diabetes Mellitus Patients with and without Diabetic Peripheral Neuropathy. Journal of Diabetes Research No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1108111
American Medical Association (AMA)
Miric, Dijana& Kisic, Bojana& Filipovic-Danic, Snezana& Grbic, Rade& Dragojevic, Ilija& Miric, Marko B.…[et al.]. Xanthine Oxidase Activity in Type 2 Diabetes Mellitus Patients with and without Diabetic Peripheral Neuropathy. Journal of Diabetes Research. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1108111
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108111