Acute Hypoglycemia Induces Painful Neuropathy and the Treatment of Coenzyme Q10
Joint Authors
Candiotti, Keith A.
Zhang, Yan Ping
Mei, Shanshan
Yang, Jinfeng
Rodriguez-Blanco, Yiliam F.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-28
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Diabetic neuropathic pain is reduced with tight glycemic control.
However, strict control increases the risk of hypoglycemic episodes, which are themselves linked to painful neuropathy.
This study explored the effects of hypoglycemia-related painful neuropathy.
Pretreatment with coenzyme Q10 (CoQ10) was performed to explore the preventive effect of CoQ10 on hypoglycemia-related acute neuropathic pain.
Two strains of mice were used and 1 unit/kg of insulin was given to induce hypoglycemia.
Mechanical sensitivity of hindpaw withdrawal thresholds was measured using von Frey filaments.
Blood glucose levels were clamped at normal levels by joint insulin and glucose injection to test whether insulin itself induced hypersensitivity.
Results suggest that the increased mechanical sensitivity after insulin injection is related to decreased blood glucose levels.
When blood glucose levels remained at a normal level by the linked administration of insulin and glucose, mice demonstrated no significant change in mechanical sensitivity.
Pretreatment with CoQ10 prevented neuropathic pain and the expression of the stress factor c-Fos.
These results support the concept that pain in the diabetic scenario can be the result of hypoglycemia and not insulin itself.
Additionally, pretreatment with CoQ10 may be a potent preventive method for the development of neuropathic pain.
American Psychological Association (APA)
Zhang, Yan Ping& Mei, Shanshan& Yang, Jinfeng& Rodriguez-Blanco, Yiliam F.& Candiotti, Keith A.. 2015. Acute Hypoglycemia Induces Painful Neuropathy and the Treatment of Coenzyme Q10. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1108120
Modern Language Association (MLA)
Zhang, Yan Ping…[et al.]. Acute Hypoglycemia Induces Painful Neuropathy and the Treatment of Coenzyme Q10. Journal of Diabetes Research No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1108120
American Medical Association (AMA)
Zhang, Yan Ping& Mei, Shanshan& Yang, Jinfeng& Rodriguez-Blanco, Yiliam F.& Candiotti, Keith A.. Acute Hypoglycemia Induces Painful Neuropathy and the Treatment of Coenzyme Q10. Journal of Diabetes Research. 2015. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1108120
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108120