Modeling and Measurement of Correlation between Blood and Interstitial Glucose Changes
Joint Authors
Shi, Ting
Li, Dachao
Li, Guoqing
Zhang, Yiming
Xu, Kexin
Lu, Luo
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-27
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
One of the most effective methods for continuous blood glucose monitoring is to continuously measure glucose in the interstitial fluid (ISF).
However, multiple physiological factors can modulate glucose concentrations and affect the lag phase between blood and ISF glucose changes.
This study aims to develop a compensatory tool for measuring the delay in ISF glucose variations in reference to blood glucose changes.
A theoretical model was developed based on biophysics and physiology of glucose transport in the microcirculation system.
Blood and interstitial fluid glucose changes were measured in mice and rats by fluorescent and isotope methods, respectively.
Computer simulation mimicked curves were fitted with data resulting from fluorescent measurements of mice and isotope measurements of rats, indicating that there were lag times for ISF glucose changes.
It also showed that there was a required diffusion distance for glucose to travel from center of capillaries to interstitial space in both mouse and rat models.
We conclude that it is feasible with the developed model to continuously monitor dynamic changes of blood glucose concentration through measuring glucose changes in ISF with high accuracy, which requires correct parameters for determining and compensating for the delay time of glucose changes in ISF.
American Psychological Association (APA)
Shi, Ting& Li, Dachao& Li, Guoqing& Zhang, Yiming& Xu, Kexin& Lu, Luo. 2016. Modeling and Measurement of Correlation between Blood and Interstitial Glucose Changes. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1108121
Modern Language Association (MLA)
Shi, Ting…[et al.]. Modeling and Measurement of Correlation between Blood and Interstitial Glucose Changes. Journal of Diabetes Research No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1108121
American Medical Association (AMA)
Shi, Ting& Li, Dachao& Li, Guoqing& Zhang, Yiming& Xu, Kexin& Lu, Luo. Modeling and Measurement of Correlation between Blood and Interstitial Glucose Changes. Journal of Diabetes Research. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1108121
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108121