Sex Differences in the Renal Function Decline of Patients with Type 2 Diabetes

Joint Authors

Nakagawa, Kazuko
Jinnouchi, Hideaki
Yoshida, Akira
Kajiwara, Ayami
Kita, Ayana
Saruwatari, Junji
Miyazaki, Hiroko
Kawata, Yuki
Morita, Kazunori
Oniki, Kentaro

Source

Journal of Diabetes Research

Issue

Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2016-05-09

Country of Publication

Egypt

No. of Pages

8

Main Subjects

Diseases
Medicine

Abstract EN

Aims.

We aimed to investigate the sex differences in the renal function decline among patients with type 2 diabetic mellitus (T2DM), focusing on the differences in the risk factors at early stage of renal dysfunction.

Methods.

A clinic-based retrospective longitudinal study (follow-up duration: 8.1±1.4 years) was conducted to assess the sex differences in the annual estimated glomerular filtration rate (eGFR) change in 344 (247 male and 97 female) Japanese T2DM patients.

The sex differences in the risk factors of annual eGFR decline were subjected to linear regression analyses.

Results.

The mean annual eGFR change was -3.5±2.7%/year in females and -2.0±2.2%/year in males (P<0.001).

Baseline retinopathy and proteinuria were significantly associated with a larger eGFR decline, irrespective of sex, while HbA1c and LDL-cholesterol levels were significantly associated with an eGFR decline in females only.

Interactive effects were observed between sex and the HbA1c, LDL-cholesterol, retinopathy, or proteinuria levels on the annual eGFR decline.

Conclusions.

The increased susceptibility to poor metabolic control seemed to contribute to a higher risk of renal dysfunction in females with T2DM.

Our study highlights the importance of aggressive therapeutic intervention to improve metabolic profiles at early stage, especially in females.

American Psychological Association (APA)

Kajiwara, Ayami& Kita, Ayana& Saruwatari, Junji& Miyazaki, Hiroko& Kawata, Yuki& Morita, Kazunori…[et al.]. 2016. Sex Differences in the Renal Function Decline of Patients with Type 2 Diabetes. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1108125

Modern Language Association (MLA)

Kajiwara, Ayami…[et al.]. Sex Differences in the Renal Function Decline of Patients with Type 2 Diabetes. Journal of Diabetes Research No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1108125

American Medical Association (AMA)

Kajiwara, Ayami& Kita, Ayana& Saruwatari, Junji& Miyazaki, Hiroko& Kawata, Yuki& Morita, Kazunori…[et al.]. Sex Differences in the Renal Function Decline of Patients with Type 2 Diabetes. Journal of Diabetes Research. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1108125

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1108125