Calpain-Calcineurin-Nuclear Factor Signaling and the Development of Atrial Fibrillation in Patients with Valvular Heart Disease and Diabetes
Joint Authors
Zhao, Yong
Cui, Guo-ming
Zhou, Nan-nan
Li, Cong
Zhang, Qing
Sun, Hui
Han, Bo
Zou, Cheng-wei
Wang, Li-juan
Li, Xiao-dong
Wang, Jian-chun
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-31
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Calpain, calcineurin (CaN), and nuclear factor of activated T cell (NFAT) play a key role in the development of atrial fibrillation.
Patients with valvular heart disease (VHD) are prone to develop atrial fibrillation (AF).
Thus, our current study was aimed at investigating whether activation of calpain-CaN-NFAT pathway is associated with the incidence of AF in the patients with VHD and diabetes.
The expressions of calpain 2 and alpha- and beta-isoforms of CaN catalytic subunit (CnA) as well as NFAT-c3 and NFAT-c4 were quantified by quantitative reverse transcription-polymerase chain reaction in atrial tissues from 77 hospitalized patients with VHD and diabetes.
The relevant protein content was measured by Western blot and calpain 2 in human atrium was localized by immunohistochemistry.
We found that the expressions of calpain 2, CnA alpha and CnA beta, and NFAT-c3 but not NFAT-c4 were significantly elevated in the samples from patients with AF compared to those with sinus rhythm (SR).
Elevated protein levels of calpain 2 and CnA were observed in patients with AF, and so was the enhanced localization of calpain 2.
We thereby concluded that CaN together with its upstream molecule, calpain 2, and its downstream effector, NFAT-c3, might contribute to the development of AF in patients with VHD and diabetes.
American Psychological Association (APA)
Zhao, Yong& Cui, Guo-ming& Zhou, Nan-nan& Li, Cong& Zhang, Qing& Sun, Hui…[et al.]. 2016. Calpain-Calcineurin-Nuclear Factor Signaling and the Development of Atrial Fibrillation in Patients with Valvular Heart Disease and Diabetes. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1108126
Modern Language Association (MLA)
Zhao, Yong…[et al.]. Calpain-Calcineurin-Nuclear Factor Signaling and the Development of Atrial Fibrillation in Patients with Valvular Heart Disease and Diabetes. Journal of Diabetes Research No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1108126
American Medical Association (AMA)
Zhao, Yong& Cui, Guo-ming& Zhou, Nan-nan& Li, Cong& Zhang, Qing& Sun, Hui…[et al.]. Calpain-Calcineurin-Nuclear Factor Signaling and the Development of Atrial Fibrillation in Patients with Valvular Heart Disease and Diabetes. Journal of Diabetes Research. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1108126
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108126