Comparison of Experimental Diabetic Periodontitis Induced by Porphyromonas gingivalis in Mice
Joint Authors
Wang, Qi
Zhang, Peng
Aprecio, Ray
Zhang, Dongjiao
Li, Hao
Ji, Ning
Mohamed, Omaima
Zhang, Wu
Li, Yiming
Ding, Yi
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-23
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Periodontitis is one of the severe complications in diabetic patients and gingival epithelium plays an initial role on the onset and progression of this disease.
However the potential mechanism is yet sufficiently understood.
Meanwhile, the research on the correlational experimental animal models was also insufficient.
Here, we established periodontitis with type 2 diabetes in db/db and Tallyho/JngJ (TH) mice and periodontitis with type 1 diabetes in streptozotocin induced diabetes C57BL/6J (STZ-C57) mice by oral infection of periodontal pathogen Porphyromonas gingivalis W50.
We demonstrated that periodontal infected mice with high blood glucose levels showed dramatically more alveolar bone loss than their counterparts, in which infected db/db mice exhibited the most bone defects.
No contrary impact could be observed between this periodontal infection and onset and severity of diabetes.
The expressions of PTPN2 were inhibited whereas the expression of JAK1, STAT1, and STAT3 increased dramatically in gingival epithelia and the serum TNF-α also significantly increased in the mice with diabetic periodontitis.
Our results indicated that the variations of inflammation-related protein expressions in gingival epithelia might lead to the phenotype differences in the mice with diabetic periodontitis.
American Psychological Association (APA)
Wang, Qi& Zhang, Peng& Aprecio, Ray& Zhang, Dongjiao& Li, Hao& Ji, Ning…[et al.]. 2016. Comparison of Experimental Diabetic Periodontitis Induced by Porphyromonas gingivalis in Mice. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1108131
Modern Language Association (MLA)
Wang, Qi…[et al.]. Comparison of Experimental Diabetic Periodontitis Induced by Porphyromonas gingivalis in Mice. Journal of Diabetes Research No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1108131
American Medical Association (AMA)
Wang, Qi& Zhang, Peng& Aprecio, Ray& Zhang, Dongjiao& Li, Hao& Ji, Ning…[et al.]. Comparison of Experimental Diabetic Periodontitis Induced by Porphyromonas gingivalis in Mice. Journal of Diabetes Research. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1108131
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108131