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Metformin Inhibits Advanced Glycation End Products-Induced Inflammatory Response in Murine Macrophages Partly through AMPK Activation and RAGENFκB Pathway Suppression
Joint Authors
Jin, Xian
Zhou, Zhong’e
Shen, Chengxing
Tang, Yong
Chen, Chengjun
Lu, Yi
Liu, Liang
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-28
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Advanced glycation end products (AGEs) are major inflammatory mediators in diabetes, affecting atherosclerosis progression via macrophages.
Metformin slows diabetic atherosclerosis progression through mechanisms that remain to be fully elucidated.
The present study of murine bone marrow derived macrophages showed that (1) AGEs enhanced proinflammatory cytokines (interleukin-1β (IL-1β), IL-6, and tumor necrosis factor-α (TNF-α)) mRNA expression, RAGE expression, and NFκB activation; (2) metformin pretreatment inhibited AGEs effects and AGEs-induced cluster designation 86 (CD86) (M1 marker) expression, while promoting CD206 (M2 marker) surface expression and anti-inflammatory cytokine (IL-10) mRNA expression; and (3) the AMPK inhibitor, Compound C, attenuated metformin effects.
In conclusion, metformin inhibits AGEs-induced inflammatory response in murine macrophages partly through AMPK activation and RAGE/NFκB pathway suppression.
American Psychological Association (APA)
Zhou, Zhong’e& Tang, Yong& Jin, Xian& Chen, Chengjun& Lu, Yi& Liu, Liang…[et al.]. 2016. Metformin Inhibits Advanced Glycation End Products-Induced Inflammatory Response in Murine Macrophages Partly through AMPK Activation and RAGENFκB Pathway Suppression. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1108133
Modern Language Association (MLA)
Zhou, Zhong’e…[et al.]. Metformin Inhibits Advanced Glycation End Products-Induced Inflammatory Response in Murine Macrophages Partly through AMPK Activation and RAGENFκB Pathway Suppression. Journal of Diabetes Research No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1108133
American Medical Association (AMA)
Zhou, Zhong’e& Tang, Yong& Jin, Xian& Chen, Chengjun& Lu, Yi& Liu, Liang…[et al.]. Metformin Inhibits Advanced Glycation End Products-Induced Inflammatory Response in Murine Macrophages Partly through AMPK Activation and RAGENFκB Pathway Suppression. Journal of Diabetes Research. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1108133
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108133