![](/images/graphics-bg.png)
The Rise and the Fall of BetatrophinANGPTL8 as an Inducer of β-Cell Proliferation
Joint Authors
Abu-Farha, Mohamed
Abubaker, Jehad
Al Madhoun, Ashraf
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-08
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Diabetes is a global health problem that is caused by impaired insulin production from pancreatic β-cells.
Efforts to regenerate β-cells have been advancing rapidly in the past two decades with progress made towards identifying new agents that induce β-cells regeneration.
ANGPTL8, also named betatrophin, has been recently identified as a hormone capable of inducing β-cells proliferation and increasing β-cells mass in rodents.
Its discovery has been cherished as a breakthrough and a game changer in the field of β-cells regeneration.
Initially, ANGPTL8 has been identified as atypical member of the angiopoietin-like protein family as a regulator of triglyceride in plasma through its interaction with ANGPTL3 and its regulation of lipoprotein lipase activity.
In this review, we will review literature on the proposed role of ANGPTL8 in β-cells proliferation, the controversy regarding this role, and the emerging data questioning its involvement in β-cells proliferation.
Additionally we will discuss new clinical data that describes its role in diabetes and the putative therapeutic targeting of this protein.
American Psychological Association (APA)
Abu-Farha, Mohamed& Al Madhoun, Ashraf& Abubaker, Jehad. 2016. The Rise and the Fall of BetatrophinANGPTL8 as an Inducer of β-Cell Proliferation. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1108134
Modern Language Association (MLA)
Abu-Farha, Mohamed…[et al.]. The Rise and the Fall of BetatrophinANGPTL8 as an Inducer of β-Cell Proliferation. Journal of Diabetes Research No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1108134
American Medical Association (AMA)
Abu-Farha, Mohamed& Al Madhoun, Ashraf& Abubaker, Jehad. The Rise and the Fall of BetatrophinANGPTL8 as an Inducer of β-Cell Proliferation. Journal of Diabetes Research. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1108134
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108134