Myocardial Perfusion and Function Are Distinctly Altered by Sevoflurane Anesthesia in Diet-Induced Prediabetic Rats
Joint Authors
Bouwman, R. A.
van den Brom, Charissa E.
Boly, Chantal A.
Bulte, Carolien S. E.
van den Akker, Rob F. P.
Kwekkeboom, Rick F. J.
Loer, Stephan A.
Boer, Christa
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-28
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Preservation of myocardial perfusion during surgery is particularly important in patients with increased risk for perioperative complications, such as diabetes.
Volatile anesthetics, like sevoflurane, have cardiodepressive effects and may aggravate cardiovascular complications.
We investigated the effect of sevoflurane on myocardial perfusion and function in prediabetic rats.
Rats were fed a western diet (WD; n = 18 ) or control diet (CD; n = 18 ) for 8 weeks and underwent (contrast) echocardiography to determine perfusion and function during baseline and sevoflurane exposure.
Myocardial perfusion was estimated based on the product of microvascular filling velocity and blood volume.
WD-feeding resulted in a prediabetic phenotype characterized by obesity, hyperinsulinemia, hyperlipidemia, glucose intolerance, and hyperglycemia.
At baseline, WD-feeding impaired myocardial perfusion and systolic function compared to CD-feeding.
Exposure of healthy rats to sevoflurane increased the microvascular filling velocity without altering myocardial perfusion but impaired systolic function.
In prediabetic rats, sevoflurane did also not affect myocardial perfusion; however, it further impaired systolic function.
Diet-induced prediabetes is associated with impaired myocardial perfusion and function in rats.
While sevoflurane further impaired systolic function, it did not affect myocardial perfusion in prediabetic rats.
Our findings suggest that sevoflurane anesthesia leads to uncoupling of myocardial perfusion and function, irrespective of the metabolic state.
American Psychological Association (APA)
van den Brom, Charissa E.& Boly, Chantal A.& Bulte, Carolien S. E.& van den Akker, Rob F. P.& Kwekkeboom, Rick F. J.& Loer, Stephan A.…[et al.]. 2015. Myocardial Perfusion and Function Are Distinctly Altered by Sevoflurane Anesthesia in Diet-Induced Prediabetic Rats. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1108144
Modern Language Association (MLA)
van den Brom, Charissa E.…[et al.]. Myocardial Perfusion and Function Are Distinctly Altered by Sevoflurane Anesthesia in Diet-Induced Prediabetic Rats. Journal of Diabetes Research No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1108144
American Medical Association (AMA)
van den Brom, Charissa E.& Boly, Chantal A.& Bulte, Carolien S. E.& van den Akker, Rob F. P.& Kwekkeboom, Rick F. J.& Loer, Stephan A.…[et al.]. Myocardial Perfusion and Function Are Distinctly Altered by Sevoflurane Anesthesia in Diet-Induced Prediabetic Rats. Journal of Diabetes Research. 2015. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1108144
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108144