Circulating Biomarkers of Diabetic Retinopathy: An Overview Based on Physiopathology
Joint Authors
Simó, Rafael
Simó-Servat, Olga
Hernández, Cristina
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-08
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Diabetic retinopathy (DR) is the main cause of working-age adult-onset blindness.
The currently available treatments for DR are applicable only at advanced stages of the disease and are associated with significant adverse effects.
In early stages of DR the only therapeutic strategy that physicians can offer is a tight control of the risk factors for DR.
Therefore, new pharmacological treatments for these early stages of the disease are required.
In order to develop therapeutic strategies for early stages of DR new diagnostic tools are urgently needed.
In this regard, circulating biomarkers could be useful to detect early disease, to identify those diabetic patients most prone to progressive worsening who ought to be followed up more often and who could obtain the most benefit from these therapies, and to monitor the effectiveness of new drugs for DR before more advanced DR stages have been reached.
Research of biomarkers for DR has been mainly based on the pathogenic mechanism involved in the development of DR (i.e., AGEs, oxidative stress, endothelial dysfunction, inflammation, and proangiogenic factors).
This review focuses on circulating biomarkers at both early and advanced stages that could be relevant for the prediction or detection of DR.
American Psychological Association (APA)
Simó-Servat, Olga& Simó, Rafael& Hernández, Cristina. 2016. Circulating Biomarkers of Diabetic Retinopathy: An Overview Based on Physiopathology. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1108146
Modern Language Association (MLA)
Simó-Servat, Olga…[et al.]. Circulating Biomarkers of Diabetic Retinopathy: An Overview Based on Physiopathology. Journal of Diabetes Research No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1108146
American Medical Association (AMA)
Simó-Servat, Olga& Simó, Rafael& Hernández, Cristina. Circulating Biomarkers of Diabetic Retinopathy: An Overview Based on Physiopathology. Journal of Diabetes Research. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1108146
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108146