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Effect of Ranirestat on Sensory and Motor Nerve Function in Japanese Patients with Diabetic Polyneuropathy: A Randomized Double-Blind Placebo-Controlled Study
Joint Authors
Satoh, Jo
Kohara, Nobuo
Sekiguchi, Kenji
Yamaguchi, Yasuyuki
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-10
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
We conducted a 26-week oral-administration study of ranirestat (an aldose reductase inhibitor) at a once-daily dose of 20 mg to evaluate its efficacy and safety in Japanese patients with diabetic polyneuropathy (DPN).
The primary endpoint was summed change in sensory nerve conduction velocity (NCV) for the bilateral sural and proximal median sensory nerves.
The sensory NCV was significantly (P=0.006) improved by ranirestat.
On clinical symptoms evaluated with the use of modified Toronto Clinical Neuropathy Score (mTCNS), obvious efficacy was not found in total score.
However, improvement in the sensory test domain of the mTCNS was significant (P=0.037) in a subgroup of patients diagnosed with neuropathy according to the TCNS severity classification.
No clinically significant effects on safety parameters including hepatic and renal functions were observed.
Our results indicate that ranirestat is effective on DPN (Japic CTI-121994).
American Psychological Association (APA)
Satoh, Jo& Kohara, Nobuo& Sekiguchi, Kenji& Yamaguchi, Yasuyuki. 2016. Effect of Ranirestat on Sensory and Motor Nerve Function in Japanese Patients with Diabetic Polyneuropathy: A Randomized Double-Blind Placebo-Controlled Study. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1108154
Modern Language Association (MLA)
Satoh, Jo…[et al.]. Effect of Ranirestat on Sensory and Motor Nerve Function in Japanese Patients with Diabetic Polyneuropathy: A Randomized Double-Blind Placebo-Controlled Study. Journal of Diabetes Research No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1108154
American Medical Association (AMA)
Satoh, Jo& Kohara, Nobuo& Sekiguchi, Kenji& Yamaguchi, Yasuyuki. Effect of Ranirestat on Sensory and Motor Nerve Function in Japanese Patients with Diabetic Polyneuropathy: A Randomized Double-Blind Placebo-Controlled Study. Journal of Diabetes Research. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1108154
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108154