CCL2 Serum Levels and Adiposity Are Associated with the Polymorphic Phenotypes -2518A on CCL2 and 64ILE on CCR2 in a Mexican Population with Insulin Resistance
Joint Authors
Navarro-Hernandez, Rosa Elena
Madrigal-Ruiz, Perla Monserrat
Guzmán-Ornelas, Milton-Omar
Corona Meraz, Fernanda-Isadora
Castro-Albarran, Jorge
Ruíz-Quezada, Sandra-Luz
Chavarria-Avila, Efraín
Sandoval-Garcia, F.
Petri, Marcelo Heron
Vázquez-Del Mercado, Mónica
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-29
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Genetic susceptibility has been described in insulin resistance (IR).
Chemokine (C-C motif) ligand-2 (CCL2) is overexpressed in white adipose tissue and is the ligand of C-C motif receptor-2 (CCR2).
The CCL2 G-2518A polymorphism is known to regulate gene expression, whereas the physiological effects of the CCR2Val64Ile polymorphism are unknown.
The aim of the study is to investigate the relationship between these polymorphisms with soluble CCL2 levels (sCCL2), metabolic markers, and adiposity.
In a cross-sectional study we included 380 Mexican-Mestizo individuals, classified with IR according to Stern criteria.
Polymorphism was identified using PCR-RFLP/sequence-specific primers.
Anthropometrics and metabolic markers were measured by routine methods and adipokines and sCCL2 by ELISA.
The CCL2 polymorphism was associated with IR (polymorphic A+ phenotype frequencies were 70.9%, 82.6%, in individuals with and without IR, resp.).
Phenotype carriers CCL2 (A+) displayed lower body mass and fat indexes, insulin and HOMA-IR, and higher adiponectin levels.
Individuals with IR presented higher sCCL2 compared to individuals without IR and was associated with CCR2 (Ile+) phenotype.
The double-polymorphic phenotype carriers (A+/Ile+) exhibited higher sCCL2 than double-wild-type phenotype carriers (A−/Ile−).
The present findings suggest that sCCL2 production possibly will be associated with the adiposity and polymorphic phenotypes of CCL2 and CCR2, in Mexican-Mestizos with IR.
American Psychological Association (APA)
Guzmán-Ornelas, Milton-Omar& Petri, Marcelo Heron& Vázquez-Del Mercado, Mónica& Chavarria-Avila, Efraín& Corona Meraz, Fernanda-Isadora& Ruíz-Quezada, Sandra-Luz…[et al.]. 2015. CCL2 Serum Levels and Adiposity Are Associated with the Polymorphic Phenotypes -2518A on CCL2 and 64ILE on CCR2 in a Mexican Population with Insulin Resistance. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1108165
Modern Language Association (MLA)
Guzmán-Ornelas, Milton-Omar…[et al.]. CCL2 Serum Levels and Adiposity Are Associated with the Polymorphic Phenotypes -2518A on CCL2 and 64ILE on CCR2 in a Mexican Population with Insulin Resistance. Journal of Diabetes Research No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1108165
American Medical Association (AMA)
Guzmán-Ornelas, Milton-Omar& Petri, Marcelo Heron& Vázquez-Del Mercado, Mónica& Chavarria-Avila, Efraín& Corona Meraz, Fernanda-Isadora& Ruíz-Quezada, Sandra-Luz…[et al.]. CCL2 Serum Levels and Adiposity Are Associated with the Polymorphic Phenotypes -2518A on CCL2 and 64ILE on CCR2 in a Mexican Population with Insulin Resistance. Journal of Diabetes Research. 2015. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1108165
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108165