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A Novel Chemically Modified Curcumin “Normalizes” Wound-Healing in Rats with Experimentally Induced Type I Diabetes: Initial Studies
Joint Authors
Johnson, Francis
Elburki, Muna S.
Zhang, Yu
McClain, Steve A.
Yu, Huiwen
Gu, Ying
Wolff, Mark
Golub, Lorne M.
Lee, Hsi-Ming
Zhang, Yazhou
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-13
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Introduction.
Impaired wound-healing in diabetics can lead to life-threatening complications, such as limb amputation, associated in part with excessive matrix metalloproteinase- (MMP-) mediated degradation of collagen and other matrix constituents.
In the current study, a novel triketonic chemically modified curcumin, CMC2.24, was tested for efficacy in healing of standardized skin wounds in streptozotocin-induced diabetic rats.
Initially, CMC2.24 was daily applied topically at 1% or 3% concentrations or administered systemically (oral intubation; 30 mg/kg); controls received vehicle treatment only.
Over 7 days, the diabetics exhibited impaired wound closure, assessed by gross and histologic measurements, compared to the nondiabetic controls.
All drug treatments significantly improved wound closure with efficacy ratings as follows: 1% 2.24 > systemic 2.24 > 3% 2.24 with no effect on the severe hyperglycemia.
In subsequent experiments, 1% CMC2.24 “normalized” wound-healing in the diabetics, whereas 1% curcumin was no more effective than 0.25% CMC2.24, and the latter remained 34% worse than normal.
MMP-8 was increased 10-fold in the diabetic wounds and topically applied 1% (but not 0.25%) CMC2.24 significantly reduced this excessive collagenase-2; MMP-13/collagenase-3 did not show significant changes.
Additional studies indicated efficacy of 1% CMC2.24 over more prolonged periods of time up to 30 days.
American Psychological Association (APA)
Zhang, Yazhou& McClain, Steve A.& Lee, Hsi-Ming& Elburki, Muna S.& Yu, Huiwen& Gu, Ying…[et al.]. 2016. A Novel Chemically Modified Curcumin “Normalizes” Wound-Healing in Rats with Experimentally Induced Type I Diabetes: Initial Studies. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1108170
Modern Language Association (MLA)
Zhang, Yazhou…[et al.]. A Novel Chemically Modified Curcumin “Normalizes” Wound-Healing in Rats with Experimentally Induced Type I Diabetes: Initial Studies. Journal of Diabetes Research No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1108170
American Medical Association (AMA)
Zhang, Yazhou& McClain, Steve A.& Lee, Hsi-Ming& Elburki, Muna S.& Yu, Huiwen& Gu, Ying…[et al.]. A Novel Chemically Modified Curcumin “Normalizes” Wound-Healing in Rats with Experimentally Induced Type I Diabetes: Initial Studies. Journal of Diabetes Research. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1108170
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108170