Recognition of ZnT8, Proinsulin, and Homologous MAP Peptides in Sardinian Children at Risk of T1D Precedes Detection of Classical Islet Antibodies
Joint Authors
Paccagnini, Daniela
Songini, Marco
Niegowska, Magdalena
Mannu, Carla
Targhetta, Clara
Sechi, Leonardo Antonio
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
As numerous studies put in evidence the increasing incidence of type 1 diabetes (T1D) in children, an early diagnosis is of great importance to define correct treatment and diet.
Currently, the identification of classical islet autoantibodies is the primary biomarker for diagnosis in subjects at risk, especially in pediatric patients.
Recent studies suggest that detection of antibodies against ZnT8 protein in preclinical phase can predict the development of T1D.
We previously demonstrated a significant association of Mycobacterium avium subspecies paratuberculosis (MAP) with T1D in adult Sardinian patients.
To enforce this finding, we investigated the presence of antibodies against ZnT8 and proinsulin (PI) with respective homologous epitopes: MAP3865 c 133 – 141 /ZnT 8 186 – 194 , MAP3865 c 125 – 133 /ZnT 8 178 – 186 , MAP2404 c 70 – 85 /P I 46 – 61 , and MAP1,4αgb p 157 – 173 /P I 64 – 80 , in 23 children at risk for T1D, formerly involved in the TRIGR study, and 22 healthy controls (HCs).
Positivity to anti-MAP and homologous human peptides was detected in 48% of at-risk subjects compared to 5,85% HCs, preceding appearance of islet autoantibodies.
Being MAP easily transmitted to humans with infected cow’s milk and detected in retail infant formulas, MAP epitopes could be present in extensively hydrolyzed formula and act as antigens stimulating β-cell autoimmunity.
American Psychological Association (APA)
Niegowska, Magdalena& Paccagnini, Daniela& Mannu, Carla& Targhetta, Clara& Songini, Marco& Sechi, Leonardo Antonio. 2015. Recognition of ZnT8, Proinsulin, and Homologous MAP Peptides in Sardinian Children at Risk of T1D Precedes Detection of Classical Islet Antibodies. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1108173
Modern Language Association (MLA)
Niegowska, Magdalena…[et al.]. Recognition of ZnT8, Proinsulin, and Homologous MAP Peptides in Sardinian Children at Risk of T1D Precedes Detection of Classical Islet Antibodies. Journal of Diabetes Research No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1108173
American Medical Association (AMA)
Niegowska, Magdalena& Paccagnini, Daniela& Mannu, Carla& Targhetta, Clara& Songini, Marco& Sechi, Leonardo Antonio. Recognition of ZnT8, Proinsulin, and Homologous MAP Peptides in Sardinian Children at Risk of T1D Precedes Detection of Classical Islet Antibodies. Journal of Diabetes Research. 2015. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1108173
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108173