Subclinical Detection of Diabetic Cardiomyopathy with MicroRNAs: Challenges and Perspectives
Joint Authors
León, Luis E.
Rani, Sweta
Fernandez, Mauricio
Larico, Martín
Calligaris, Sebastián D.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-06
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The prevalence of cardiac diabetic diseases has been increased around the world, being the most common cause of death and disability among diabetic patients.
In particular, diabetic cardiomyopathy is characterized with a diastolic dysfunction and cardiac remodelling without signs of hypertension and coronary artery diseases.
In an early stage, it is an asymptomatic disease; however, clinical studies demonstrate that diabetic myocardia are more vulnerable to injury derived by acute myocardial infarct and are the worst prognosis for rehabilitation.
Currently, biochemical and imaging diagnostic methods are unable to detect subclinical manifestation of the disease (prior to diastolic dysfunction).
In this review, we elaborately discuss the current scientific evidences to propose circulating microRNAs as promising biomarkers for early detection of diabetic cardiomyopathy and, then, to identify patients at high risk of diabetic cardiomyopathy development.
Moreover, here we summarise the research strategies to identify miRNAs as potential biomarkers, present limitations, challenges, and future perspectives.
American Psychological Association (APA)
León, Luis E.& Rani, Sweta& Fernandez, Mauricio& Larico, Martín& Calligaris, Sebastián D.. 2015. Subclinical Detection of Diabetic Cardiomyopathy with MicroRNAs: Challenges and Perspectives. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1108186
Modern Language Association (MLA)
León, Luis E.…[et al.]. Subclinical Detection of Diabetic Cardiomyopathy with MicroRNAs: Challenges and Perspectives. Journal of Diabetes Research No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1108186
American Medical Association (AMA)
León, Luis E.& Rani, Sweta& Fernandez, Mauricio& Larico, Martín& Calligaris, Sebastián D.. Subclinical Detection of Diabetic Cardiomyopathy with MicroRNAs: Challenges and Perspectives. Journal of Diabetes Research. 2015. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1108186
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108186