Association between -308GA TNFA Polymorphism and Susceptibility to Type 2 Diabetes Mellitus: A Systematic Review
Joint Authors
Luna, Geisa Izetti
Silva, Izabel Cristina Rodrigues da
Sanchez, Mauro Niskier
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-16
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Diabetes mellitus (DM) is considered to be a worldwide epidemic disease and its type 2 form comprises more than 95% of all cases.
Tumor necrosis factor-alpha (TNF-α) is a proinflammatory cytokine.
Its dysregulation has been implicated in a variety of human diseases, including type 2 diabetes mellitus (T2DM).
The control of expression of this cytokine is associated with insulin resistance and has a strong genetic influence.
In order to understand this relationship, the literature from all case-control studies since 2000 to date was reviewed.
The genotypes frequency results presented in ten publications with different ethnicities were compared.
The correlation between the TNFA promoter genotypes and the risk of developing T2DM remains controversial due to the many discrepancies between the different studies available.
Ethnic differences may play a role in these conflicting results, since the distribution of TNFA promoter polymorphisms is distinctive between individuals of dissimilar racial origin.
Hence, although the relationship between T2DM incidence and presence of polymorphisms at position -308 of the TNFA gene is not entirely clear, the results of these studies suggest the need for further investigation.
American Psychological Association (APA)
Luna, Geisa Izetti& Silva, Izabel Cristina Rodrigues da& Sanchez, Mauro Niskier. 2016. Association between -308GA TNFA Polymorphism and Susceptibility to Type 2 Diabetes Mellitus: A Systematic Review. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1108198
Modern Language Association (MLA)
Luna, Geisa Izetti…[et al.]. Association between -308GA TNFA Polymorphism and Susceptibility to Type 2 Diabetes Mellitus: A Systematic Review. Journal of Diabetes Research No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1108198
American Medical Association (AMA)
Luna, Geisa Izetti& Silva, Izabel Cristina Rodrigues da& Sanchez, Mauro Niskier. Association between -308GA TNFA Polymorphism and Susceptibility to Type 2 Diabetes Mellitus: A Systematic Review. Journal of Diabetes Research. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1108198
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108198