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Postnatal Hematopoiesis and Gut Microbiota in NOD Mice Deviate from C57BL6 Mice
Joint Authors
Nielsen, D. S.
Hansen, A. K.
Hasselby, Jane Preuss
Damlund, Dina Silke Malling
Metzdorff, Stine Broeng
Wiese, Maria
Lundsager, Mia
Buschard, Karsten Stig
Frøkiær, Hanne
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-10
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Neonatal studies in different mouse strains reveal that early life colonization affects the development of adaptive immunity in mice.
The nonobese diabetic (NOD) mouse spontaneously develops autoimmune diabetes, but neonatal studies of NOD mice are lacking.
We hypothesized that NOD mice deviate from another much used mouse strain, C57BL/6, with respect to postnatal microbiota and/or hematopoiesis and compared this in newborn mice of dams housed under the same conditions.
A distinct bacteria profile rich in staphylococci was found at postnatal days (PND) 1–4 in NOD mice.
Furthermore, a distinct splenic cell profile high in a granulocytic phenotype was evident in the neonatal NOD mice whereas neonatal C57BL/6 mice showed a profile rich in monocytes.
Neonatal expression of Reg3g and Muc2 in the gut was deviating in NOD mice and coincided with fewer bacteria attaching to the Mucosal surface in NOD compared to C57BL/6 mice.
American Psychological Association (APA)
Damlund, Dina Silke Malling& Metzdorff, Stine Broeng& Hasselby, Jane Preuss& Wiese, Maria& Lundsager, Mia& Nielsen, D. S.…[et al.]. 2015. Postnatal Hematopoiesis and Gut Microbiota in NOD Mice Deviate from C57BL6 Mice. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1108200
Modern Language Association (MLA)
Damlund, Dina Silke Malling…[et al.]. Postnatal Hematopoiesis and Gut Microbiota in NOD Mice Deviate from C57BL6 Mice. Journal of Diabetes Research No. 2016 (2016), pp.1-15.
https://search.emarefa.net/detail/BIM-1108200
American Medical Association (AMA)
Damlund, Dina Silke Malling& Metzdorff, Stine Broeng& Hasselby, Jane Preuss& Wiese, Maria& Lundsager, Mia& Nielsen, D. S.…[et al.]. Postnatal Hematopoiesis and Gut Microbiota in NOD Mice Deviate from C57BL6 Mice. Journal of Diabetes Research. 2015. Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1108200
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108200