Resting Heart Rate Does Not Predict Cardiovascular and Renal Outcomes in Type 2 Diabetic Patients

Abstract EN

Elevated resting heart rate (RHR) has been associated with increased risk of mortality and cardiovascular events.

Limited data are available so far in type 2 diabetic (T2DM) subjects with no study focusing on progressive renal decline specifically.

Aims of our study were to verify RHR as a simple and reliable predictor of adverse disease outcomes in T2DM patients.

A total of 421 T2DM patients with variable baseline stage of diabetic kidney disease (DKD) were prospectively followed.

A history of the cardiovascular disease was present in 81 (19.2%) patients at baseline, and DKD (glomerular filtration rate < 60 mL/min or proteinuria) was present in 328 (77.9%) at baseline.

Progressive renal decline was defined as a continuous rate of glomerular filtration rate loss ≥ 3.3% per year.

Resting heart rate was not significantly higher in subjects with cardiovascular disease or DKD at baseline compared to those without.

Using time-to-event analyses, significant differences in the cumulative incidence of the studied outcomes, that is, progression of DKD (and specifically progressive renal decline), major advanced cardiovascular event, and all-cause mortality, between RHR

We did not ascertain predictive value of the RHR for the renal or cardiovascular outcomes in T2DM subjects in Czech Republic.