Impaired Thermogenesis and a Molecular Signature for Brown Adipose Tissue in Id2 Null Mice
Joint Authors
Zhou, Peng
Robles-Murguia, Maricela
Mathew, Deepa
Duffield, Giles E.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-10
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Inhibitor of DNA binding 2 (ID2) is a helix-loop-helix transcriptional repressor rhythmically expressed in many adult tissues.
Our previous studies have demonstrated that Id2 null mice have sex-specific elevated glucose uptake in brown adipose tissue (BAT).
Here we further explored the role of Id2 in the regulation of core body temperature over the circadian cycle and the impact of Id2 deficiency on genes involved in insulin signaling and adipogenesis in BAT.
We discovered a reduced core body temperature in Id2−/− mice.
Moreover, in Id2−/− BAT, 30 genes including Irs1, PPARs, and PGC-1s were identified as differentially expressed in a sex-specific pattern.
These data provide valuable insights into the impact of Id2 deficiency on energy homeostasis of mice in a sex-specific manner.
American Psychological Association (APA)
Zhou, Peng& Robles-Murguia, Maricela& Mathew, Deepa& Duffield, Giles E.. 2016. Impaired Thermogenesis and a Molecular Signature for Brown Adipose Tissue in Id2 Null Mice. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1108213
Modern Language Association (MLA)
Zhou, Peng…[et al.]. Impaired Thermogenesis and a Molecular Signature for Brown Adipose Tissue in Id2 Null Mice. Journal of Diabetes Research No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1108213
American Medical Association (AMA)
Zhou, Peng& Robles-Murguia, Maricela& Mathew, Deepa& Duffield, Giles E.. Impaired Thermogenesis and a Molecular Signature for Brown Adipose Tissue in Id2 Null Mice. Journal of Diabetes Research. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1108213
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108213