The Role of AGERAGE Signaling in Diabetes-Mediated Vascular Calcification
Joint Authors
Kay, Amber M.
Simpson, C. LaShan
Stewart, James A.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-07-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
AGE/RAGE signaling has been a well-studied cascade in many different disease states, particularly diabetes.
Due to the complex nature of the receptor and multiple intersecting pathways, the AGE/RAGE signaling mechanism is still not well understood.
The purpose of this review is to highlight key areas of AGE/RAGE mediated vascular calcification as a complication of diabetes.
AGE/RAGE signaling heavily influences both cellular and systemic responses to increase bone matrix proteins through PKC, p38 MAPK, fetuin-A, TGF-β, NFκB, and ERK1/2 signaling pathways in both hyperglycemic and calcification conditions.
AGE/RAGE signaling has been shown to increase oxidative stress to promote diabetes-mediated vascular calcification through activation of Nox-1 and decreased expression of SOD-1.
AGE/RAGE signaling in diabetes-mediated vascular calcification was also attributed to increased oxidative stress resulting in the phenotypic switch of VSMCs to osteoblast-like cells in AGEs-induced calcification.
Researchers found that pharmacological agents and certain antioxidants decreased the level of calcium deposition in AGEs-induced diabetes-mediated vascular calcification.
By understanding the role the AGE/RAGE signaling cascade plays diabetes-mediated vascular calcification will allow for pharmacological intervention to decrease the severity of this diabetic complication.
American Psychological Association (APA)
Kay, Amber M.& Simpson, C. LaShan& Stewart, James A.. 2016. The Role of AGERAGE Signaling in Diabetes-Mediated Vascular Calcification. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1108215
Modern Language Association (MLA)
Kay, Amber M.…[et al.]. The Role of AGERAGE Signaling in Diabetes-Mediated Vascular Calcification. Journal of Diabetes Research No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1108215
American Medical Association (AMA)
Kay, Amber M.& Simpson, C. LaShan& Stewart, James A.. The Role of AGERAGE Signaling in Diabetes-Mediated Vascular Calcification. Journal of Diabetes Research. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1108215
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108215