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Sweet Bones: The Pathogenesis of Bone Alteration in Diabetes
Author
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-29
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Diabetic patients have increased fracture risk.
The pathogenesis underlying the status of bone alterations in diabetes mellitus is not completely understood but is multifactorial.
The major deficits appear to be related to a deficit in mineralized surface area, a decrement in the rate of mineral apposition, deceased osteoid surface, depressed osteoblast activity, and decreased numbers of osteoclasts due to abnormal insulin signaling pathway.
Other prominent features of diabetes mellitus are an increased urinary excretion of calcium and magnesium, accumulation of advanced glycation end products, and oxidative stress leading to sweet bones (altered bone’s strength, metabolism, and structure).
Every diabetic patient should be assessed for risk factors for fractures and osteoporosis.
The pathogenesis of the bone alterations in diabetes mellitus as well as their molecular mechanisms needs further study.
American Psychological Association (APA)
Al-Hariri, Mohammed. 2016. Sweet Bones: The Pathogenesis of Bone Alteration in Diabetes. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1108222
Modern Language Association (MLA)
Al-Hariri, Mohammed. Sweet Bones: The Pathogenesis of Bone Alteration in Diabetes. Journal of Diabetes Research No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1108222
American Medical Association (AMA)
Al-Hariri, Mohammed. Sweet Bones: The Pathogenesis of Bone Alteration in Diabetes. Journal of Diabetes Research. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1108222
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108222