Oxidative Stress in Diabetic Nephropathy with Early Chronic Kidney Disease
Joint Authors
Miranda-Díaz, Alejandra Guillermina
Pazarín-Villaseñor, Leonardo
Yanowsky-Escatell, Francisco Gerardo
Andrade-Sierra, Jorge
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-07-20
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The increase in the prevalence of diabetes mellitus (DM) and the secondary kidney damage produces diabetic nephropathy (DN).
Early nephropathy is defined as the presence of microalbuminuria (30–300 mg/day), including normal glomerular filtration rate (GFR) or a mildly decreased GFR (60–89 mL/min/1.73 m2), with or without overt nephropathy.
The earliest change caused by DN is hyperfiltration with proteinuria.
The acceptable excretion rate of albumin in urine is <30 mg/day.
Albuminuria represents the excretion of >300 mg/day.
Chronic kidney disease (CKD) is characterized by abnormalities in renal function that persist for >3 months with health implications.
Alterations in the redox state in DN are caused by the persistent state of hyperglycemia and the increase in advanced glycation end products (AGEs) with ability to affect the renin-angiotensin system and the transforming growth factor-beta (TGF-β), producing chronic inflammation and glomerular and tubular hypertrophy and favoring the appearance of oxidative stress.
In DN imbalance between prooxidant/antioxidant processes exists with an increase in reactive oxygen species (ROS).
The overproduction of ROS diminishes expression of the antioxidant enzymes (manganese superoxide dismutase, glutathione peroxidase, and catalase).
The early detection of CKD secondary to DN and the timely identification of patients would permit decreasing its impact on health.
American Psychological Association (APA)
Miranda-Díaz, Alejandra Guillermina& Pazarín-Villaseñor, Leonardo& Yanowsky-Escatell, Francisco Gerardo& Andrade-Sierra, Jorge. 2016. Oxidative Stress in Diabetic Nephropathy with Early Chronic Kidney Disease. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1108225
Modern Language Association (MLA)
Miranda-Díaz, Alejandra Guillermina…[et al.]. Oxidative Stress in Diabetic Nephropathy with Early Chronic Kidney Disease. Journal of Diabetes Research No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1108225
American Medical Association (AMA)
Miranda-Díaz, Alejandra Guillermina& Pazarín-Villaseñor, Leonardo& Yanowsky-Escatell, Francisco Gerardo& Andrade-Sierra, Jorge. Oxidative Stress in Diabetic Nephropathy with Early Chronic Kidney Disease. Journal of Diabetes Research. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1108225
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108225