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Comment on “Puerarin Improves Diabetic Aorta Injury by Inhibiting NADPH Oxidase-Derived Oxidative Stress in STZ-Induced Diabetic Rats”
Joint Authors
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-2, 2 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-23
Country of Publication
Egypt
No. of Pages
2
Main Subjects
Abstract EN
We read with great interest the article showing that streptozotocin- (STZ-) induced diabetic rats given puerarin can significantly reduce the serum levels of insulin, glycated hemoglobin, PGE2, endothelin, H2O2, and NO, improve the pathological alterations, and inhibit the expression of ICAM-1, LOX-1, and NOX2 [1].
In addition, puerarin strongly reduced the number of cells showing positive staining for ICAM-1, NOX2, NOX4, and NF-κB p65.
Interestingly, Li et al.
also showed that STZ-induced diabetes mellitus and aorta lesion can be improved by treatment with puerarin, where puerarin is able to downregulate the levels of cholesterol, low density lipoprotein, P-selectin, oxidative low density lipoprotein, and the expression of VCAM in the aorta which were significantly inhibited [2].
These data indicated that puerarin has played a certain role in preventing aorta or vessels by inhibiting expression of adhesion molecules.
American Psychological Association (APA)
Xie, Qiang& Zhong, Jian& Li, Jun. 2016. Comment on “Puerarin Improves Diabetic Aorta Injury by Inhibiting NADPH Oxidase-Derived Oxidative Stress in STZ-Induced Diabetic Rats”. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-2.
https://search.emarefa.net/detail/BIM-1108235
Modern Language Association (MLA)
Xie, Qiang…[et al.]. Comment on “Puerarin Improves Diabetic Aorta Injury by Inhibiting NADPH Oxidase-Derived Oxidative Stress in STZ-Induced Diabetic Rats”. Journal of Diabetes Research No. 2016 (2016), pp.1-2.
https://search.emarefa.net/detail/BIM-1108235
American Medical Association (AMA)
Xie, Qiang& Zhong, Jian& Li, Jun. Comment on “Puerarin Improves Diabetic Aorta Injury by Inhibiting NADPH Oxidase-Derived Oxidative Stress in STZ-Induced Diabetic Rats”. Journal of Diabetes Research. 2016. Vol. 2016, no. 2016, pp.1-2.
https://search.emarefa.net/detail/BIM-1108235
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108235