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Hypoxia Alters the Expression of Dipeptidyl Peptidase 4 and Induces Developmental Remodeling of Human Preadipocytes
Joint Authors
Zorec, Robert
Chowdhury, Helena H.
Velebit, Jelena
Radić, Nataša
Frančič, Vito
Kreft, Marko
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-03
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Dipeptidyl peptidase 4 (DPP4), a transmembrane protein, has been identified in human adipose tissue and is considered to be associated with obesity-related type 2 diabetes.
Since adipose tissue is relatively hypoxic in obese participants, we investigated the expression of DPP4 in human preadipocytes (hPA) and adipocytes in hypoxia, during differentiation and upon insulin stimulation.
The results show that DPP4 is abundantly expressed in hPA but very sparsely in adipocytes.
During differentiation in vitro, the expression of DPP4 in hPA is reduced on the addition of differentiation medium, indicating that this protein can be hPA marker.
Long term hypoxia altered the expression of DPP4 in hPA.
In in vitro hypoxic conditions the protease activity of shed DPP4 is reduced; however, in the presence of insulin, the increase in DPP4 expression is potentiated by hypoxia.
American Psychological Association (APA)
Chowdhury, Helena H.& Velebit, Jelena& Radić, Nataša& Frančič, Vito& Kreft, Marko& Zorec, Robert. 2016. Hypoxia Alters the Expression of Dipeptidyl Peptidase 4 and Induces Developmental Remodeling of Human Preadipocytes. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1108241
Modern Language Association (MLA)
Chowdhury, Helena H.…[et al.]. Hypoxia Alters the Expression of Dipeptidyl Peptidase 4 and Induces Developmental Remodeling of Human Preadipocytes. Journal of Diabetes Research No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1108241
American Medical Association (AMA)
Chowdhury, Helena H.& Velebit, Jelena& Radić, Nataša& Frančič, Vito& Kreft, Marko& Zorec, Robert. Hypoxia Alters the Expression of Dipeptidyl Peptidase 4 and Induces Developmental Remodeling of Human Preadipocytes. Journal of Diabetes Research. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1108241
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108241