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A Systems Biology Overview on Human Diabetic Nephropathy: From Genetic Susceptibility to Post-Transcriptional and Post-Translational Modifications
Joint Authors
Gesualdo, Loreto
Conserva, Francesca
Papale, Massimo
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-23, 23 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-20
Country of Publication
Egypt
No. of Pages
23
Main Subjects
Abstract EN
Diabetic nephropathy (DN), a microvascular complication occurring in approximately 20–40% of patients with type 2 diabetes mellitus (T2DM), is characterized by the progressive impairment of glomerular filtration and the development of Kimmelstiel-Wilson lesions leading to end-stage renal failure (ESRD).
The causes and molecular mechanisms mediating the onset of T2DM chronic complications are yet sketchy and it is not clear why disease progression occurs only in some patients.
We performed a systematic analysis of the most relevant studies investigating genetic susceptibility and specific transcriptomic, epigenetic, proteomic, and metabolomic patterns in order to summarize the most significant traits associated with the disease onset and progression.
The picture that emerges is complex and fascinating as it includes the regulation/dysregulation of numerous biological processes, converging toward the activation of inflammatory processes, oxidative stress, remodeling of cellular function and morphology, and disturbance of metabolic pathways.
The growing interest in the characterization of protein post-translational modifications and the importance of handling large datasets using a systems biology approach are also discussed.
American Psychological Association (APA)
Conserva, Francesca& Gesualdo, Loreto& Papale, Massimo. 2015. A Systems Biology Overview on Human Diabetic Nephropathy: From Genetic Susceptibility to Post-Transcriptional and Post-Translational Modifications. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-23.
https://search.emarefa.net/detail/BIM-1108255
Modern Language Association (MLA)
Conserva, Francesca…[et al.]. A Systems Biology Overview on Human Diabetic Nephropathy: From Genetic Susceptibility to Post-Transcriptional and Post-Translational Modifications. Journal of Diabetes Research No. 2016 (2016), pp.1-23.
https://search.emarefa.net/detail/BIM-1108255
American Medical Association (AMA)
Conserva, Francesca& Gesualdo, Loreto& Papale, Massimo. A Systems Biology Overview on Human Diabetic Nephropathy: From Genetic Susceptibility to Post-Transcriptional and Post-Translational Modifications. Journal of Diabetes Research. 2015. Vol. 2016, no. 2016, pp.1-23.
https://search.emarefa.net/detail/BIM-1108255
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108255