Using Metabolomic Profiles as Biomarkers for Insulin Resistance in Childhood Obesity: A Systematic Review
Joint Authors
Liu, Yujia
Sun, Chenglin
Zhao, Xue
Han, Qing
Gang, Xiaokun
Wang, Guixia
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-07-19
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
A growing body of evidence has shown the intimate relationship between metabolomic profiles and insulin resistance (IR) in obese adults, while little is known about childhood obesity.
In this review, we searched available papers addressing metabolomic profiles and IR in obese children from inception to February 2016 on MEDLINE, Web of Science, the Cochrane Library, ClinicalTrials.gov, and EMASE.
HOMA-IR was applied as surrogate markers of IR and related metabolic disorders at both baseline and follow-up.
To minimize selection bias, two investigators independently completed this work.
After critical selection, 10 studies (including 2,673 participants) were eligible and evaluated by using QUADOMICS for quality assessment.
Six of the 10 studies were classified as “high quality.” Then we generated all the metabolites identified in each study and found amino acid metabolism and lipid metabolism were the main affected metabolic pathways in obese children.
Among identified metabolites, branched-chain amino acids (BCAAs), aromatic amino acids (AAAs), and acylcarnitines were reported to be associated with IR as biomarkers most frequently.
Additionally, BCAAs and tyrosine seemed to be relevant to future metabolic risk in the long-term follow-up cohorts, emphasizing the importance of early diagnosis and prevention strategy.
Because of limited scale and design heterogeneity of existing studies, future studies might focus on validating above findings in more large-scale and longitudinal studies with elaborate design.
American Psychological Association (APA)
Zhao, Xue& Gang, Xiaokun& Liu, Yujia& Sun, Chenglin& Han, Qing& Wang, Guixia. 2016. Using Metabolomic Profiles as Biomarkers for Insulin Resistance in Childhood Obesity: A Systematic Review. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1108266
Modern Language Association (MLA)
Zhao, Xue…[et al.]. Using Metabolomic Profiles as Biomarkers for Insulin Resistance in Childhood Obesity: A Systematic Review. Journal of Diabetes Research No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1108266
American Medical Association (AMA)
Zhao, Xue& Gang, Xiaokun& Liu, Yujia& Sun, Chenglin& Han, Qing& Wang, Guixia. Using Metabolomic Profiles as Biomarkers for Insulin Resistance in Childhood Obesity: A Systematic Review. Journal of Diabetes Research. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1108266
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108266