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High Intensity Aerobic Exercise Training Improves Deficits of Cardiovascular Autonomic Function in a Rat Model of Type 1 Diabetes Mellitus with Moderate Hyperglycemia
Joint Authors
McDonald, Matthew W.
Grisé, Kenneth N.
Olver, T. Dylan
Dey, Adwitia
Jiang, Mao
Lacefield, James C.
Shoemaker, J. Kevin
Melling, C. W. James
Noble, Earl G.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-18
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Indices of cardiovascular autonomic neuropathy (CAN) in experimental models of Type 1 diabetes mellitus (T1DM) are often contrary to clinical data.
Here, we investigated whether a relatable insulin-treated model of T1DM would induce deficits in cardiovascular (CV) autonomic function more reflective of clinical results and if exercise training could prevent those deficits.
Sixty-four rats were divided into four groups: sedentary control (C), sedentary T1DM (D), control exercise (CX), or T1DM exercise (DX).
Diabetes was induced via multiple low-dose injections of streptozotocin and blood glucose was maintained at moderate hyperglycemia (9–17 mM) through insulin supplementation.
Exercise training consisted of daily treadmill running for 10 weeks.
Compared to C, D had blunted baroreflex sensitivity, increased vascular sympathetic tone, increased serum neuropeptide Y (NPY), and decreased intrinsic heart rate.
In contrast, DX differed from D in all measures of CAN (except NPY), including heart rate variability.
These findings demonstrate that this T1DM model elicits deficits and exercise-mediated improvements to CV autonomic function which are reflective of clinical T1DM.
American Psychological Association (APA)
Grisé, Kenneth N.& Olver, T. Dylan& McDonald, Matthew W.& Dey, Adwitia& Jiang, Mao& Lacefield, James C.…[et al.]. 2016. High Intensity Aerobic Exercise Training Improves Deficits of Cardiovascular Autonomic Function in a Rat Model of Type 1 Diabetes Mellitus with Moderate Hyperglycemia. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1108268
Modern Language Association (MLA)
Grisé, Kenneth N.…[et al.]. High Intensity Aerobic Exercise Training Improves Deficits of Cardiovascular Autonomic Function in a Rat Model of Type 1 Diabetes Mellitus with Moderate Hyperglycemia. Journal of Diabetes Research No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1108268
American Medical Association (AMA)
Grisé, Kenneth N.& Olver, T. Dylan& McDonald, Matthew W.& Dey, Adwitia& Jiang, Mao& Lacefield, James C.…[et al.]. High Intensity Aerobic Exercise Training Improves Deficits of Cardiovascular Autonomic Function in a Rat Model of Type 1 Diabetes Mellitus with Moderate Hyperglycemia. Journal of Diabetes Research. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1108268
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108268