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Antidiabetic Effect of Young and Old Ethanolic Leaf Extracts of Vernonia amygdalina: A Comparative Study
Joint Authors
Asante, Du-Bois
Effah-Yeboah, Emmanuel
Barnes, Precious
Abban, Heckel Amoabeng
Ofori, Eric Gyamerah
Dadzie, Joseph Budu
Ameyaw, E. O.
Boampong, J. N.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-16
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The young leaves of Vernonia amygdalina are often utilized as vegetable and for medicinal purpose compared to the old leaves.
This study was designed to evaluate and compare the antidiabetic effects between ethanolic leaf extracts of old and young V.
amygdalina on streptozotocin (STZ) induced diabetic rat for four weeks.
Preliminary screening of both young and old ethanolic extracts revealed the presence of the same phytochemicals except flavonoids which was only present in the old V.
amygdalina.
Difference in antioxidant power between the young and old leaf extracts was statistically significant ( p < 0.05 ).
Both leaf extracts produced a significant ( p < 0.05 ) antihyperglycaemic effect.
Also results from treated rats revealed increasing effect in some haematological parameters.
Similarly, the higher dose (300 mg/kg) of both extracts significantly ( p < 0.05 ) reduced serum ALT, AST, and ALP levels as compared to the diabetic control rats.
Results also showed significant ( p < 0.05 ) decrease in LDL-C and VLDL-C in the extract-treated rats with a corresponding increase in HDL-C, as compared to the diabetic control rats.
Moreover histopathological analysis revealed ameliorative effect of pathological insults induced by the STZ in the pancreas, liver, and spleen, most significantly the regeneration of the beta cells of the islets of Langerhans in treated rats.
American Psychological Association (APA)
Asante, Du-Bois& Effah-Yeboah, Emmanuel& Barnes, Precious& Abban, Heckel Amoabeng& Ameyaw, E. O.& Boampong, J. N.…[et al.]. 2016. Antidiabetic Effect of Young and Old Ethanolic Leaf Extracts of Vernonia amygdalina: A Comparative Study. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1108271
Modern Language Association (MLA)
Asante, Du-Bois…[et al.]. Antidiabetic Effect of Young and Old Ethanolic Leaf Extracts of Vernonia amygdalina: A Comparative Study. Journal of Diabetes Research No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1108271
American Medical Association (AMA)
Asante, Du-Bois& Effah-Yeboah, Emmanuel& Barnes, Precious& Abban, Heckel Amoabeng& Ameyaw, E. O.& Boampong, J. N.…[et al.]. Antidiabetic Effect of Young and Old Ethanolic Leaf Extracts of Vernonia amygdalina: A Comparative Study. Journal of Diabetes Research. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1108271
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108271