![](/images/graphics-bg.png)
Metformin Treatment Prevents Sedentariness Related Damages in Mice
Joint Authors
Luzi, Livio
Benedini, Stefano
Codella, Roberto
Montesano, Anna
Terruzzi, Ileana M.
Senesi, Pamela
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-30
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Metformin (METF), historical antihyperglycemic drug, is a likely candidate for lifespan extension, treatment and prevention of sedentariness damages, insulin resistance, and obesity.
Skeletal muscle is a highly adaptable tissue, capable of hypertrophy response to resistance training and of regeneration after damage.
Aims of this work were to investigate METF ability to prevent sedentariness damage and to enhance skeletal muscle function.
Sedentary 12-week-old C57BL/6 mice were treated with METF (250 mg/kg per day, in drinking water) for 60 days.
METF role on skeletal muscle differentiation was studied in vitro using murine C2C12 myoblasts.
Muscular performance evaluation revealed that METF enhanced mice physical performance (Estimated VO 2max ).
Biochemical analyses of hepatic and muscular tissues indicated that in liver METF increased AMPK and CAMKII signaling.
In contrast, METF inactivated ERKs, the principal kinases involved in hepatic stress.
In skeletal muscle, METF activated AKT, key kinase in skeletal muscle mass maintenance.
In in vitro studies, METF did not modify the C2C12 proliferation capacity, while it positively influenced the differentiation process and myotube maturation.
In conclusion, our novel results suggest that METF has a positive action not only on the promotion of healthy aging but also on the prevention of sedentariness damages.
American Psychological Association (APA)
Senesi, Pamela& Montesano, Anna& Luzi, Livio& Codella, Roberto& Benedini, Stefano& Terruzzi, Ileana M.. 2015. Metformin Treatment Prevents Sedentariness Related Damages in Mice. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1108273
Modern Language Association (MLA)
Senesi, Pamela…[et al.]. Metformin Treatment Prevents Sedentariness Related Damages in Mice. Journal of Diabetes Research No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1108273
American Medical Association (AMA)
Senesi, Pamela& Montesano, Anna& Luzi, Livio& Codella, Roberto& Benedini, Stefano& Terruzzi, Ileana M.. Metformin Treatment Prevents Sedentariness Related Damages in Mice. Journal of Diabetes Research. 2015. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1108273
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108273