Impact of the Type of Continuous Insulin Administration on Metabolism in a Diabetic Rat Model
Joint Authors
Dal, Stéphanie
Bietiger, William
Seyfritz, Elodie
Jeandidier, Nathalie
Maillard, Elisa
Sigrist, Séverine
Peronet, C.
Sookhareea, C.
Langlois, A.
Mura, C.
Schaschkow, A.
Pinget, M.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-07-18
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Exogenous insulin is the only treatment available for type 1 diabetic patients and is mostly administered by subcutaneous (SC) injection in a basal and bolus scheme using insulin pens (injection) or pumps (preimplanted SC catheter).
Some divergence exists between these two modes of administration, since pumps provide better glycaemic control compared to injections in humans.
The aim of this study was to compare the impacts of two modes of insulin administration (single injections of long-acting insulin or pump delivery of rapid-acting insulin) at the same dosage (4 IU/200 g/day) on rat metabolism and tissues.
The rat weight and blood glucose levels were measured periodically after treatment.
Immunostaining for signs of oxidative stress and for macrophages was performed on the liver and omental tissues.
The continuous insulin delivery by pumps restored normoglycaemia, which induced the reduction of both reactive oxygen species and macrophage infiltration into the liver and omentum.
Injections controlled the glucose levels for only a short period of time and therefore tissue stress and inflammation were elevated.
In conclusion, the insulin administration mode has a crucial impact on rat metabolic parameters, which has to be taken into account when studies are designed.
American Psychological Association (APA)
Schaschkow, A.& Mura, C.& Dal, Stéphanie& Langlois, A.& Seyfritz, Elodie& Sookhareea, C.…[et al.]. 2016. Impact of the Type of Continuous Insulin Administration on Metabolism in a Diabetic Rat Model. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1108276
Modern Language Association (MLA)
Schaschkow, A.…[et al.]. Impact of the Type of Continuous Insulin Administration on Metabolism in a Diabetic Rat Model. Journal of Diabetes Research No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1108276
American Medical Association (AMA)
Schaschkow, A.& Mura, C.& Dal, Stéphanie& Langlois, A.& Seyfritz, Elodie& Sookhareea, C.…[et al.]. Impact of the Type of Continuous Insulin Administration on Metabolism in a Diabetic Rat Model. Journal of Diabetes Research. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1108276
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108276