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Plasma C1qTNF-Related Protein-9 Levels Are Associated with Atherosclerosis in Patients with Type 2 Diabetes without Renal Dysfunction
Joint Authors
Mori, Katsuhito
Asada, Mariko
Morioka, Tomoaki
Yamazaki, Yuko
Kakutani, Yoshinori
Kawarabayashi, Reina
Motoyama, Koka
Fukumoto, Shinya
Shioi, Atsushi
Shoji, Tetsuo
Emoto, Masanori
Inaba, Masaaki
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-14
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Aim.
C1q/tumor necrosis factor-related protein-9 (CTRP9), a paralog of adiponectin, is expressed in adipose tissue.
CTRP9 exerts protective effects against obesity and atherosclerosis in rodents.
We investigated the association between plasma CTRP9 levels and atherosclerosis in patients with type 2 diabetes.
Methods.
We included 419 patients with type 2 diabetes, 161 of whom had chronic kidney disease (CKD).
Fasting plasma CTRP9 and total adiponectin levels were measured with enzyme-linked immunosorbent assay.
The intima-media thickness (IMT) of the common carotid artery was measured with ultrasonography.
Results.
Plasma CTRP9 levels were higher in the CKD group than in the non-CKD group.
Plasma CTRP9 levels were positively correlated with carotid IMT in the non-CKD group.
Multivariate analyses revealed that plasma CTRP9 levels were positively associated with carotid IMT in the non-CKD group, independent of age, sex, body mass index, adiponectin, and other cardiovascular risk factors.
However, plasma CTRP9 levels were not associated with carotid IMT in the CKD group.
Conclusion.
Plasma CTRP9 levels are associated with atherosclerosis in diabetic patients without CKD, independently of obesity, adiponectin, and traditional cardiovascular risk factors.
This study indicates a potential role of CTRP9 in atherosclerosis progression in human type 2 diabetes.
American Psychological Association (APA)
Asada, Mariko& Morioka, Tomoaki& Yamazaki, Yuko& Kakutani, Yoshinori& Kawarabayashi, Reina& Motoyama, Koka…[et al.]. 2016. Plasma C1qTNF-Related Protein-9 Levels Are Associated with Atherosclerosis in Patients with Type 2 Diabetes without Renal Dysfunction. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1108289
Modern Language Association (MLA)
Asada, Mariko…[et al.]. Plasma C1qTNF-Related Protein-9 Levels Are Associated with Atherosclerosis in Patients with Type 2 Diabetes without Renal Dysfunction. Journal of Diabetes Research No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1108289
American Medical Association (AMA)
Asada, Mariko& Morioka, Tomoaki& Yamazaki, Yuko& Kakutani, Yoshinori& Kawarabayashi, Reina& Motoyama, Koka…[et al.]. Plasma C1qTNF-Related Protein-9 Levels Are Associated with Atherosclerosis in Patients with Type 2 Diabetes without Renal Dysfunction. Journal of Diabetes Research. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1108289
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108289