Interaction between Mean Arterial Pressure and HbA1c in Prediction of Cardiovascular Disease Hospitalisation: A Population-Based Case-Control Study
Joint Authors
Yu, Dahai
Zhao, Zhanzheng
Simmons, David
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-13
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objective.
To explore the relationship between mean arterial pressure (MAP), HbA1c, and cardiovascular (CV) hospitalisation risk in type 2 diabetes.
Design.
Population-based case-control study.
Settings.
Primary and secondary care level in Cambridgeshire, United Kingdom.
Participants.
588 patients with type 2 diabetes from 18 English general practices recording a CV hospitalisation in 2009–2011 were included.
Risk-set sampling was used to select 2920 gender, age, and practice matched control type 2 diabetes patients.
Main Outcome Measure.
Conditional logistic regression was used to explore further dose-response relationships between MAP, HbA1c, and CV hospitalisation risk.
Results.
The relationship between MAP and CV hospitalisation was nonlinear ( P < 0.001 for linearity test).
The MAP associated with the lowest CV hospitalisation risk was 97 (95% CI: 93–101) mmHg.
An interaction between MAP and HbA1c for increased risk of cardiovascular hospitalisation was observed among those with HbA1c < 7% (53 mmol/mol) and MAP < 97 mmHg.
Conclusions.
In type 2 diabetes, MAP is a good predictor of CV hospitalisation risk.
CV hospitalisation is lowest with a MAP between 93 and 101 mmHg.
CV hospitalisation was particularly high among those with both a low MAP and a lower HbA1c.
American Psychological Association (APA)
Yu, Dahai& Zhao, Zhanzheng& Simmons, David. 2016. Interaction between Mean Arterial Pressure and HbA1c in Prediction of Cardiovascular Disease Hospitalisation: A Population-Based Case-Control Study. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1108294
Modern Language Association (MLA)
Yu, Dahai…[et al.]. Interaction between Mean Arterial Pressure and HbA1c in Prediction of Cardiovascular Disease Hospitalisation: A Population-Based Case-Control Study. Journal of Diabetes Research No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1108294
American Medical Association (AMA)
Yu, Dahai& Zhao, Zhanzheng& Simmons, David. Interaction between Mean Arterial Pressure and HbA1c in Prediction of Cardiovascular Disease Hospitalisation: A Population-Based Case-Control Study. Journal of Diabetes Research. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1108294
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108294