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Update on RAAS Modulation for the Treatment of Diabetic Cardiovascular Disease
Joint Authors
Fabris, Bruno
Bernardi, Stella
Michelli, Andrea
Zuolo, Giulia
Candido, Riccardo
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-29
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Since the advent of insulin, the improvements in diabetes detection and the therapies to treat hyperglycemia have reduced the mortality of acute metabolic emergencies, such that today chronic complications are the major cause of morbidity and mortality among diabetic patients.
More than half of the mortality that is seen in the diabetic population can be ascribed to cardiovascular disease (CVD), which includes not only myocardial infarction due to premature atherosclerosis but also diabetic cardiomyopathy.
The importance of renin-angiotensin-aldosterone system (RAAS) antagonism in the prevention of diabetic CVD has demonstrated the key role that the RAAS plays in diabetic CVD onset and development.
Today, ACE inhibitors and angiotensin II receptor blockers represent the first line therapy for primary and secondary CVD prevention in patients with diabetes.
Recent research has uncovered new dimensions of the RAAS and, therefore, new potential therapeutic targets against diabetic CVD.
Here we describe the timeline of paradigm shifts in RAAS understanding, how diabetes modifies the RAAS, and what new parts of the RAAS pathway could be targeted in order to achieve RAAS modulation against diabetic CVD.
American Psychological Association (APA)
Bernardi, Stella& Michelli, Andrea& Zuolo, Giulia& Candido, Riccardo& Fabris, Bruno. 2016. Update on RAAS Modulation for the Treatment of Diabetic Cardiovascular Disease. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-17.
https://search.emarefa.net/detail/BIM-1108304
Modern Language Association (MLA)
Bernardi, Stella…[et al.]. Update on RAAS Modulation for the Treatment of Diabetic Cardiovascular Disease. Journal of Diabetes Research No. 2016 (2016), pp.1-17.
https://search.emarefa.net/detail/BIM-1108304
American Medical Association (AMA)
Bernardi, Stella& Michelli, Andrea& Zuolo, Giulia& Candido, Riccardo& Fabris, Bruno. Update on RAAS Modulation for the Treatment of Diabetic Cardiovascular Disease. Journal of Diabetes Research. 2016. Vol. 2016, no. 2016, pp.1-17.
https://search.emarefa.net/detail/BIM-1108304
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108304