Synaptosomal Protein of 25 kDa (Snap25) Polymorphisms Associated with Glycemic Parameters in Type 2 Diabetes Patients
Joint Authors
Guerini, Franca
Clerici, Mario
Alokail, Majed
Mohammed, Abdul Khader
Al-Daghri, Nasser M.
Costa, Andrea S.
Zanzottera, Milena
Alenad, Amal M.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-08
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
A possible role of Snap25 polymorphisms in type 2 diabetes mellitus (T2DM) was evaluated by analyzing three SNPs within intron 1 in a region known to affect the gene expression in vitro.
Genomic DNA from 1019 Saudi individuals (489 confirmed T2DM and 530 controls) was genotyped for SNPs rs363039, rs363043, and rs363050 in Snap25 using the TaqMan Genotyping Assay.
Significantly higher levels of fasting glucose and HbA1c were detected in T2DM patients carrying the rs363050 (AG/GG) genotypes compared to the (AA) genotype (f=4.41, df=1, and p=0.03 and f=5.31, df=1, and p=0.03, resp.).
In these same patients, insulin levels were significantly decreased compared to the (AA) individuals (f=7.29, df=1, and p=0.009).
Significant associations were detected between rs363050 (AG/GG) genotypes and increasing fasting glucose levels (p=0.01 and OR: 1.05), HbA1c levels (OR: 5.06 and p=0.02), and lower insulinemia (p=0.03 and OR: 0.95) in T2DM patients.
The minor Snap25 rs363050 (G) allele, which results in a reduced expression of Snap25, is associated with altered glycemic parameters in T2DM possibly because of reduced functionality in the exocytotic machinery leading to suboptimal release of insulin.
American Psychological Association (APA)
Al-Daghri, Nasser M.& Costa, Andrea S.& Alokail, Majed& Zanzottera, Milena& Alenad, Amal M.& Mohammed, Abdul Khader…[et al.]. 2015. Synaptosomal Protein of 25 kDa (Snap25) Polymorphisms Associated with Glycemic Parameters in Type 2 Diabetes Patients. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1108306
Modern Language Association (MLA)
Al-Daghri, Nasser M.…[et al.]. Synaptosomal Protein of 25 kDa (Snap25) Polymorphisms Associated with Glycemic Parameters in Type 2 Diabetes Patients. Journal of Diabetes Research No. 2016 (2016), pp.1-4.
https://search.emarefa.net/detail/BIM-1108306
American Medical Association (AMA)
Al-Daghri, Nasser M.& Costa, Andrea S.& Alokail, Majed& Zanzottera, Milena& Alenad, Amal M.& Mohammed, Abdul Khader…[et al.]. Synaptosomal Protein of 25 kDa (Snap25) Polymorphisms Associated with Glycemic Parameters in Type 2 Diabetes Patients. Journal of Diabetes Research. 2015. Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1108306
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108306