Islet Brain 1 Protects Insulin Producing Cells against Lipotoxicity
Joint Authors
Plaisance, Valérie
Annicotte, Jean-Sébastien
Abderrahmani, Amar
Waeber, Gérard
Ezanno, Hélène
Pawlowski, Valérie
Brajkovic, Saška
Ferdaoussi, Mourad
Zmuda, Erik
Hai, Tsonwin
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-09
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Chronic intake of saturated free fatty acids is associated with diabetes and may contribute to the impairment of functional beta cell mass.
Mitogen activated protein kinase 8 interacting protein 1 also called islet brain 1 (IB1) is a candidate gene for diabetes that is required for beta cell survival and glucose-induced insulin secretion (GSIS).
In this study we investigated whether IB1 expression is required for preserving beta cell survival and function in response to palmitate.
Chronic exposure of MIN6 and isolated rat islets cells to palmitate led to reduction of the IB1 mRNA and protein content.
Diminution of IB1 mRNA and protein level relied on the inducible cAMP early repressor activity and proteasome-mediated degradation, respectively.
Suppression of IB1 level mimicked the harmful effects of palmitate on the beta cell survival and GSIS.
Conversely, ectopic expression of IB1 counteracted the deleterious effects of palmitate on the beta cell survival and insulin secretion.
These findings highlight the importance in preserving the IB1 content for protecting beta cell against lipotoxicity in diabetes.
American Psychological Association (APA)
Brajkovic, Saška& Ferdaoussi, Mourad& Pawlowski, Valérie& Ezanno, Hélène& Plaisance, Valérie& Zmuda, Erik…[et al.]. 2015. Islet Brain 1 Protects Insulin Producing Cells against Lipotoxicity. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1108317
Modern Language Association (MLA)
Brajkovic, Saška…[et al.]. Islet Brain 1 Protects Insulin Producing Cells against Lipotoxicity. Journal of Diabetes Research No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1108317
American Medical Association (AMA)
Brajkovic, Saška& Ferdaoussi, Mourad& Pawlowski, Valérie& Ezanno, Hélène& Plaisance, Valérie& Zmuda, Erik…[et al.]. Islet Brain 1 Protects Insulin Producing Cells against Lipotoxicity. Journal of Diabetes Research. 2015. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1108317
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108317