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The Effect of Tianmai Xiaoke Pian on Insulin Resistance through PI3-KAKT Signal Pathway
Joint Authors
Wang, Nana
Han, Ping
Li, Tiegang
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-10
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
In the clinical setting, given the potential adverse effects of thiazolidinediones and biguanides, we often have difficulty in treatment that no other insulin sensitizers are available for use in type 2 diabetic mellitus (T2DM) patients.
Tianmai Xiaoke Pian (TMXKP) is a traditional Chinese medicine tablet, which is comprised of chromium picolinate, Tianhuafen, Maidong, and Wuweizi.
To understand its mechanism of action on insulin resistance, TMXKP (50 mg/kg orally) was tested in T2DM rats (induced by a high-fat diet and streptozotocin).
Eight weeks later, fasting blood glucose (FBG) and oral glucose tolerance tests (OGTT) were performed.
Area under the curve (AUC) and homeostatic model assessment of insulin resistance (HOMA-IR) were calculated, and PI3-K/AKT signal pathway-related genes and proteins were tested by reverse transcription-polymerase chain reaction (RT-PCR) and western blot analysis in muscle, adipose, and liver tissues, respectively.
TMXKP significantly reduced FBG, OGTT, AUC, and HOMA-IR in diabetic rats P<0.05.
Furthermore, we also observed that TMXKP could significantly decrease IRS-1, IRS-2, PI3-K p85α, and AKT2 gene expression and also IRS-1, IRS-2, PI3-K, AKT2, and p-AKT2 protein expression levels P<0.05 in diabetic rats.
These findings confirm that TMXKP can alleviate insulin resistance in T2DM rats through the PI3K/AKT pathway.
Thus TMXKP appears to be a promising insulin sensitizer.
American Psychological Association (APA)
Wang, Nana& Li, Tiegang& Han, Ping. 2015. The Effect of Tianmai Xiaoke Pian on Insulin Resistance through PI3-KAKT Signal Pathway. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1108321
Modern Language Association (MLA)
Wang, Nana…[et al.]. The Effect of Tianmai Xiaoke Pian on Insulin Resistance through PI3-KAKT Signal Pathway. Journal of Diabetes Research No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1108321
American Medical Association (AMA)
Wang, Nana& Li, Tiegang& Han, Ping. The Effect of Tianmai Xiaoke Pian on Insulin Resistance through PI3-KAKT Signal Pathway. Journal of Diabetes Research. 2015. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1108321
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108321