Delay in the Detrended Fluctuation Analysis Crossover Point as a Risk Factor for Type 2 Diabetes Mellitus

Joint Authors

Varela, Manuel
Rodriguez, Carmen
Vargas, Borja
García-Carretero, Rafael
Vigil, Luis

Source

Journal of Diabetes Research

Issue

Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2016-05-16

Country of Publication

Egypt

No. of Pages

6

Main Subjects

Diseases
Medicine

Abstract EN

Detrended Fluctuation Analysis (DFA) measures the complexity of a glucose time series obtained by means of a Continuous Glucose Monitoring System (CGMS) and has proven to be a sensitive marker of glucoregulatory dysfunction.

Furthermore, some authors have observed a crossover point in the DFA, signalling a change of dynamics, arguably dependent on the beta-insular function.

We investigate whether the characteristics of this crossover point have any influence on the risk of developing type 2 diabetes mellitus (T2DM).

To this end we recruited 206 patients at increased risk of T2DM (because of obesity, essential hypertension, or a first-degree relative with T2DM).

A CGMS time series was obtained, from which the DFA and the crossover point were calculated.

Patients were then followed up every 6 months for a mean of 17.5 months, controlling for the appearance of T2DM diagnostic criteria.

The time to crossover point was a significant predictor risk of developing T2DM, even after adjusting for other variables.

The angle of the crossover was not predictive by itself but became significantly protective when the model also considered the crossover point.

In summary, both a delay and a blunting of the crossover point predict the development of T2DM.

American Psychological Association (APA)

Varela, Manuel& Vigil, Luis& Rodriguez, Carmen& Vargas, Borja& García-Carretero, Rafael. 2016. Delay in the Detrended Fluctuation Analysis Crossover Point as a Risk Factor for Type 2 Diabetes Mellitus. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1108327

Modern Language Association (MLA)

Varela, Manuel…[et al.]. Delay in the Detrended Fluctuation Analysis Crossover Point as a Risk Factor for Type 2 Diabetes Mellitus. Journal of Diabetes Research No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1108327

American Medical Association (AMA)

Varela, Manuel& Vigil, Luis& Rodriguez, Carmen& Vargas, Borja& García-Carretero, Rafael. Delay in the Detrended Fluctuation Analysis Crossover Point as a Risk Factor for Type 2 Diabetes Mellitus. Journal of Diabetes Research. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1108327

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1108327